Results 81 to 90 of about 29,691 (246)

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source

Melittin-Related Peptides Interfere with Sandfly Fever Naples Virus Infection by Interacting with Heparan Sulphate

Microorganisms, 2023
Emerging viruses pose an important global public health challenge, and early action is needed to control their spread. The Bunyaviridae family contains a great number of arboviruses which are potentially pathogenic for humans.
Annalisa Chianese, Carla Zannella, Francesca Palma, Laura Di Clemente, Alessandra Monti, Nunzianna Doti, Anna De Filippis, Massimiliano Galdiero   +7 more
doaj   +1 more source

Lettuce Big‐Vein Associated Virus ORF3 Encodes a Functional 30K Movement Protein

Molecular Plant Pathology, Volume 26, Issue 9, September 2025.
AlphaFold2 + FoldSeek structure guided search predicts the movement protein of lettuce big‐vein associated virus despite low sequence similarity. ABSTRACT Movement proteins (MPs) modulate the size exclusion limit of plasmodesmata—membrane‐lined channels connecting plant cells—thereby allowing cell‐to‐cell movement and systemic spread of plant viruses ...
Willem E. W. Schravesande, Machiel V. Cligge, Raoul Frijters, Adriaan Verhage, Harrold A. van den Burg   +4 more
wiley   +1 more source

Comprehensive evaluation of nucleic acid amplification methods widely used for generic detection of sandfly-borne phleboviruses

Microbiology Spectrum
Sandfly-borne phleboviruses (SBPs), which cause sandfly fever, aseptic meningitis, encephalitis, and meningoencephalitis, are emerging pathogens of major public health concern.
Ceylan Polat, Nazli Ayhan, Koray Ergünay, Remi N. Charrel   +3 more
doaj   +1 more source

Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins [PDF]

, 2005
Background Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans.
Fernando Lisa, Haferkamp Sebastian, Schwarz Tino F, Feldmann Heinz, Flick Ramon   +4 more
core   +2 more sources

Medicinal Plant‐Derived Caffeoylquinic Acids as Inhibitors of Rift Valley Fever Virus: A Computational Study

ChemistrySelect, Volume 10, Issue 12, March 26, 2025.
Caffeoylquinic acids derived from medicinal plants were evaluated for their potential as inhibitors of the Rift Valley Fever Virus, specifically targeting the LRP1‐CR17 protein. The study employed DFT, molecular docking, and molecular dynamics simulations to analyze these compounds. The results showed strong binding affinities to the LRP1‐CR17 receptor,
Garland K. More, Charmy Twala, Kgaugelo C. Tapala, Raymond T. Makola, Gerhard Prinsloo   +4 more
wiley   +1 more source

Overview of West Nile Virus and Sandfly-borne Phlebovirus Infections in Anatolia

Journal of Microbiology and Infectious Diseases, 2014
Arthropod-borne (arbo) viruses are trafinsmitted to the susceptible hosts by blood-feeding arthropods such as mosquitoes, sandflies and ticks. Arboviral infections have had a significant global public health impact during the last decades due to their ...
Koray Ergunay, Zeliha Kocak Tufan
doaj   +1 more source

Single-Dose Intranasal Treatment with DEF201 (Adenovirus Vectored Consensus Interferon) Prevents Lethal Disease Due to Rift Valley Fever Virus Challenge

Viruses, 2014
Rift Valley fever virus (RVFV) causes severe disease in humans and ungulates. The virus can be transmitted by mosquitoes, direct contact with infected tissues or fluids, or aerosol, making it a significant biological threat for which there is no approved
Brian B. Gowen, Jane Ennis, Kevin W. Bailey, Zachary Vest, Dionna Scharton, Eric J. Sefing, Jeffrey D. Turner   +6 more
doaj   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B., Dong, C., Dong, H., Elliott, R., Li, P.   +4 more
core   +1 more source

Establishment of an Early Prediction Model for Severe Fever With Thrombocytopenia Syndrome‐Associated Encephalitis

Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.
ABSTRACT Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease primarily transmitted by ticks. The development of encephalitis in SFTS patients significantly increases the risk of adverse outcomes. However, the understanding of SFTS‐associated encephalitis (SFTSAE) is still limited. This study aimed to identify
Yijiang Liu, Naisheng Zhu, Zimeng Qin, Chenzhe He, Jiaqi Li, Hongbo Zhang, Ke Cao, Wenkui Yu   +7 more
wiley   +1 more source