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Study on the effect of exposure to polyhexamethylene guanidine-phosphate (PHMG-p) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on infectious pneumonia susceptibility

Annual Meeting of the Japanese Society of Toxicology
PARK, Jiyoung, CHOI, Jiwon, SONG, Mi-Kyung, LEE, Kyuhong   +3 more
openaire   +1 more source

Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution

Toxicology Letters, 2018
Polyhexamethylene guanidine (PHMG) has been widely used in the industry owing to its excellent biocidal, anti-corrosive, and anti-biofouling properties. In Korea, consumers exposed to PHMG-phosphate (PHMG-P)-containing humidifier disinfectant have begun to suffer from fibrotic lung injury-related symptoms for unknown reasons.
Eun-Jung Park, Jaerak Chang, Kyuhong Lee
exaly   +4 more sources

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Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats

Archives of Toxicology, 2020
Polyhexamethylene guanidine phosphate (PHMG-p) was used as a humidifier disinfectant in Korea. PHMG induced severe pulmonary fibrosis in Koreans. The objective of this study was to elucidate mechanism of pulmonary toxicity caused by PHMG-p in rats using multi-omics analysis.
Su Hyun Lee, Hyung Sik Kim, Hye Gwang Jeong   +2 more
exaly   +3 more sources

The Anti-Fibrotic Effects of CG-745, an HDAC Inhibitor, in Bleomycin and PHMG-Induced Mouse Models

Molecules, 2019
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with poor prognosis and progression to lung fibrosis related to genetic factors as well as environmental factors.
Hak Ryul Kim, Hyo-Jin Kim, Hyunju Cha
exaly   +2 more sources

Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice

Archives of Toxicology
Jung Dae Lee, Hyang Yeon Kim, Jueng-Eun Im, Handule Lee, Juyoung Park, Kwangsik Park, Keunsoo Kang, Hye Gwang Jeong, Sehyun Chae, Daehee Hwang, Beom Seok Han, Wan-Seob Cho, Suhkmann Kim, Kyu-Bong Kim   +13 more
openaire   +1 more source

The influence of modified polyhexamethylene guanidine PHMG on the biodegradation of polylactide

International Biodeterioration and Biodegradation, 2013
Maciej Walczak, Agnieszka Richert
exaly  

MALDI-TOF Analysis of Polyhexamethylene Guanidine (PHMG) Oligomers Used as a Commercial Antibacterial Humidifier Disinfectant

Bulletin of the Korean Chemical Society, 2013
Han Bin Oh, Jung-Hwan Kwon
exaly  

In vitro and in vivo evaluation of antibacterial activity of polyhexamethylene guanidine (PHMG)-loaded TiO2 nanotubes

Biomedical Materials (Bristol), 2020
Fengfeng Wu, Xuesheng Jiang, Mingchao Jin   +2 more
exaly  

Quantitative MALDI-TOF mass spectrometric analysis of biocidal polyhexamethylene guanidine (PHMG) oligomers in consumer products

International Journal of Mass Spectrometry, 2019
Han Bin Oh, Bongjin Moon, Jung-Hwan Kwon
exaly  

Acute Cardiovascular Toxicity of Sterilizers, PHMG, and PGH: Severe Inflammation in Human Cells and Heart Failure in Zebrafish

Cardiovascular Toxicology, 2012
Kyung-Hyun Cho
exaly