Results 1 to 10 of about 714,665 (318)

Regulation of Cardiac PKA Signaling by cAMP and Oxidants

Antioxidants, 2021
Pathologies, such as cancer, inflammatory and cardiac diseases are commonly associated with long-term increased production and release of reactive oxygen species referred to as oxidative stress.
Friederike Cuello, Friedrich W. Herberg, Konstantina Stathopoulou, Philipp Henning, Simon Diering   +4 more
doaj   +1 more source

Organic Phosphorus Substantially Contributes to Crop Plant Nutrition in Soils with Low Phosphorus Availability

Agronomy, 2021
To evaluate phosphorus (P) availability and the role of microorganisms in P dynamics in the barley rhizosphere, we constructed a rhizobox using two arable Andosols under different fertilization management regimens and cultivated barley (Hordeum vulgare L.
Hitoshi Moro, Ho-Dong Park, Takashi Kunito   +2 more
doaj   +1 more source

Using Biochar and Vermiwash to Improve Biological Activities of Soil

Agriculture, 2022
The recycling of key nutrients and bioenergy from waste materials is a goal of sustainable agriculture. The co-application of biochar and a vermicompost solution (vermiwash) could enhance the positive effects of both materials on soil biomass and ...
Michelangelo Becagli, Iduna Arduini, Roberto Cardelli   +2 more
doaj   +1 more source

Targeting Phosphatases and Kinases: How to Checkmate Cancer

Frontiers in Cell and Developmental Biology, 2021
Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as
Alice Turdo, Caterina D’Accardo, Antonino Glaviano, Gaetana Porcelli, Cristina Colarossi, Lorenzo Colarossi, Marzia Mare, Naida Faldetta, Chiara Modica, Giuseppe Pistone, Maria Rita Bongiorno, Matilde Todaro, Matilde Todaro, Giorgio Stassi   +13 more
doaj   +1 more source

Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Toxins, 2020
The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in host-cells, eventually leading to senescence or apoptosis ...
Benoît J. Pons, Nicolas Loiseau, Saleha Hashim, Soraya Tadrist, Gladys Mirey, Julien Vignard   +5 more
doaj   +1 more source

Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin

Journal of Extracellular Vesicles, 2021
As novel mediators of cell‐to‐cell signalling, small extracellular vesicles (sEVs) play a critical role in physiological and pathophysiological processes. To date, the molecular mechanisms that support sEV generation are incompletely understood.
Yuefei Zhang, Yiqing Li, Pan Liu, Dacheng Gong, Hui Zhou, Wenjuan Li, Huilun Zhang, Wenfang Zheng, Jiaqi Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke   +11 more
doaj   +1 more source

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate

Biomolecules, 2022
Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network.
Helen M. Wise, Adam Harris, Nisha Kriplani, Adam Schofield, Helen Caldwell, Mark J. Arends, Ian M. Overton, Nick R. Leslie   +7 more
doaj   +1 more source

A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease

Biomolecules, 2022
Protein tyrosine phosphatase receptor gamma (PTPRG) is known to interact with and regulate several tyrosine kinases, exerting a tumor suppressor role in several type of cancers.
Christian Boni, Carlo Laudanna, Claudio Sorio   +2 more
doaj   +1 more source

Bacillus velezensis AR1 mediated plant nourishing through solubilization of hardly soluble phosphorus nutrient sources

Cogent Food & Agriculture, 2023
Phosphorus (P) plays a tremendous and determinant role in plant growth. However, its availability is hampered by the presence of metallic ions in soils.
Regassa Ayana Bayisa
doaj   +1 more source

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth

FEBS Open Bio, 2021
Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver
Rajan Pandey, Priya Gupta, Asif Mohmmed, Pawan Malhotra, Dinesh Gupta   +4 more
doaj   +1 more source