Results 51 to 60 of about 1,424,154 (388)

Epileptic encephalopathy caused by biallelic mutation in PPM1D: a case report

Journal of Biochemical and Clinical Genetics, 2018
Background: PPM1D gene encodes for metal-dependent protein phosphatase. Its function includes the inhibition of some tumor suppressor genes, DNA damage response, and cell cycle control.
Hind AlMaghthawi, Marwan Nashabat, Majid Alfadhel   +2 more
doaj   +1 more source

Proper Delay of Phosphorus Application Promotes Wheat Growth and Nutrient Uptake under Low Phosphorus Condition

Agriculture, 2023
It is widely known that root morphology has different response mechanisms at different phosphorus (P) levels. However, the effects of P application times on wheat (Triticum aestivum L.) root morphology and, therefore, on growth and nutrient uptake are ...
Huixuan Yi, Shengchao Hu, Yulin Zhang, Xudong Wang, Zhenqing Xia, Yuting Lei, Min Duan   +6 more
doaj   +1 more source

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

American Journal of Human Genetics, 2004
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting approximately 1% of the adult population worldwide, with an estimated heritability of 60%.
A. Begovich, V. Carlton, L. Honigberg, S. Schrodi, A. Chokkalingam, H. Alexander, K. Ardlie, Qiqing Huang, Ashley M. Smith, J. Spoerke, Marion T. Conn, Monica Chang, Sheng-Yung P. Chang, R. Saiki, J. Catanese, Diane U. Leong, Veronica E. Garcia, L. McAllister, D. Jeffery, Annette Lee, F. Batliwalla, E. Remmers, L. Criswell, M. Seldin, D. Kastner, C. Amos, J. Sninsky, P. Gregersen   +27 more
semanticscholar   +1 more source

Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes [PDF]

, 2005
Background During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase.
Golden, E.B., Grasso-Knight, G., Leboy, P.S., Reilly, G.C.   +3 more
core   +3 more sources

Okadaic Acid: A Tool to Study the Hippo Pathway

Marine Drugs, 2013
Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor.
Yutaka Hata, Sainawaer Maimaiti, Shikshya Timalsina   +2 more
doaj   +1 more source

Bacillus velezensis AR1 mediated plant nourishing through solubilization of hardly soluble phosphorus nutrient sources

Cogent Food & Agriculture, 2023
Phosphorus (P) plays a tremendous and determinant role in plant growth. However, its availability is hampered by the presence of metallic ions in soils.
Regassa Ayana Bayisa
doaj   +1 more source

??????????????? ????????? ????????? ?????? ??? ???????????? [PDF]

, 2015
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Hwang, Jae-Sam, Jo, Da-Eun, Jun, Mira, Kang, Byoung Heon, Lee, An-Jung, Lee, Ji-Eun, Park, Hye-Kyung, Youn, Kumju, Yun, Eun-Young   +8 more
core   +1 more source

DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]

, 2009
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core   +2 more sources

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

eLife, 2018
Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function. Here,
Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, James S Fraser   +9 more
doaj   +1 more source