Results 121 to 130 of about 5,041,800 (310)
Protective immune response against Rhodococcus equi: An innate immunity‐focused review
Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira +4 more
wiley +1 more source
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
Nature Communications, 2016 A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation
Petter Holland +15 more
semanticscholar +1 more source
The FEBS Journal, EarlyView.Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun +5 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.This study introduces an integrated analytical and bioinformatics platform for high‐throughput tracing of lipid metabolism using bioorthogonal alkyne fatty acids and optimized LC‐MS workflow. Applied to human fibrosarcoma cells, the method traced fatty acid metabolism, revealing nuances in sphingolipid routing and metabolic bottlenecks, highlighting ...
Palina Nepachalovich +7 more
wiley +2 more sources
A rapid and sensitive radiochemical assay for phosphatidic acid phosphohydrolase activity
Journal of Lipid Research, 1977 A technique is described for the radiochemical assay of phosphatidic acid phosphohydrolase activity in rat brain. Radiochemically pure 32P-labeled phosphatidic acid of known specific radioactivity and structure, which was biosynthesized in vitro by the ...
T J Flynn, D S Deshmukh, R A Pieringer
doaj
Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. [PDF]
, 2016 ObjectiveTo determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis
Boyle, David +6 more
core +2 more sources
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, EarlyView.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
A comparative study of eicosapentaenoic acid metabolism by human platelets in vivo and in vitro.
Journal of Lipid Research, 1985 During long-term dietary n-3 fatty acid supplementation, eicosapentaenoic acid (EPA) is not incorporated into phosphatidylinositol or -serine of human platelets in vivo and is not detectable in phosphatidic acid upon stimulation with thrombin.
C von Schacky +3 more
doaj
Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic Acid in Arabidopsis. [PDF]
, 2012 International audienceRemodeling of actin filament arrays in response to biotic and abiotic stimuli is thought to require precise control over the generation and availability of filament ends.
Blanchoin, Laurent +5 more
core +3 more sources
A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.
Angewandte Chemie, 2016 Phosphatidic acid (PA) is a potent lipid secondary messenger, the synthesis of which is tightly regulated in both space and time. Established tools for detecting PA involve ex vivo analysis and do not provide information on the subcellular locations ...
Timothy W. Bumpus, Jeremy M. Baskin
semanticscholar +1 more source