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Phosphatidic acid- and phosphatidylserine-binding proteins

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses.
Nicholas T. Ktistakis, Catherine Stace
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Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.

DNA and Cell Biology, 1998
Phosphatidic acid (PA) and diacylglycerol (DG) are lipids involved in signal transduction and in structural membrane-lipid biosynthesis in cells. Phosphatidic acid phosphatase (PAP) catalyzes the conversion of PA to DG. This enzyme exists in at least two
D. Leung, C. Tompkins, T. White
semanticscholar   +1 more source

Transport of phosphatidic acid within the mitochondrion

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
Transfer of phosphatidic acid from the outer to the inner membrane within intact rat liver mitochondria was assessed by measuring the ratio of lipid 32P to the marker enzyme of the outer membrane, rotenone-insensitive NADH-cytochrome c reductase, in the outer and inner membrane fractions obtained after incubation of mitochondria under conditions for ...
Józef Zborowski   +2 more
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Phosphatidic Acid Phosphatases in Seed Plants [PDF]

open access: possible, 2009
Phosphatidic acid phosphatase (PAP) dephosphorylates phosphatidic acid (PA) to yield diacylglycerol (DAG) and inorganic phosphate (Pi). In seed plants, PAP functions both as a crucial enzyme for membrane lipid biosynthesis and an attenuator for PA signal.
Nakamura, Y., Ohta, H.
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Phosphatidic Acid as a Precursor of Phosphoinositide in the Thyroid

Endocrinology, 1972
Previous reports on the incorporation of 32P into thyroid slice phosphatidic acid (PA) and phosphoinositide (PI) have claimed that the specific activity (SA) of the PI is greater than that of the PA. This would be inconsistent with the generally accepted biosynthetic sequence in which PA is a precursor of PI.
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Pulmonary phosphatidic acid phosphatase. A comparative study of the aqueously dispersed phosphatidate-dependent and membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activities of rat lung

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
1. The properties of the aqueously dispersed phosphatidate-dependent phosphatidic acid phosphatase (EC 3.1.3.4) activities of rat lung have been studied in microsomal and cytosol preparations and compared with the properties of the membrane-bound phosphatidate-dependent activities. 2.
Paul G. Casola   +4 more
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Characterization by infrared spectroscopy of the interaction of a cardiotoxin with phosphatidic acid and with binary mixtures of phosphatidic acid and phosphatidylcholine

Biochemistry, 1992
The effect of cardiotoxin IIa from Naja mossambica mossambica, a small basic protein extracted from snake venom, on dimyristoylphosphatidic acid (DMPA) and on equimolar mixtures of DMPA and dimyristoylphosphatidylcholine (DMPC) has been studied by Fourier transform infrared spectroscopy.
Gaétan Laroche   +3 more
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Phase Behavior of Phosphatidic Acid

1991
Phosphatidic acids have a propensity for forming smectic (lamellar) phases. Under physiological conditions phosphatidic acids bear one negative charge/molecule and phosphatidate bilayers swell continuously with increasing water content similar to other negatively charged lipid bilayers.
B.-Z. Lin, Helmut Hauser, C.-C. Yin
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Enzymatic synthesis of lysophosphatidic acid and phosphatidic acid

Enzyme and Microbial Technology, 1999
Immobilised 1,3-specific lipase from Rhizopus arrhizus was used as catalyst for the esterification of dl-glycero-3-phosphate and fatty acid or fatty acid vinyl ester in a solvent-free system. With lauric acid vinyl ester as acyl donor, a(w) 95%). With oleic acid, maximum conversions of 55% were obtained at low water activities.
Carmen Virto   +2 more
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Phosphatidic acids and derivatives: V) Synthesis of bisglycol‐phosphatidic acids, starting from monoacylglycols

Recueil des Travaux Chimiques des Pays-Bas, 1954
AbstractThe preparation and some properties of three bisglycol‐phosphatidic acids, containing stearic, palmitic or myristic acid as component acid, are described.
J. van Gijzen, P. E. Verkade
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