Results 151 to 160 of about 31,592 (359)

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice

Journal of Lipid Research, 2005
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro.
Michele K. Wu, Hideyuki Hyogo, Suresh K. Yadav, Phyllis M. Novikoff, David E. Cohen   +4 more
doaj  

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Environmentally-Sensitive Vesicles for Controlled Drug Delivery [PDF]

, 1990
The potential uses of phospholipid vesicles in drug delivery have been widely discussed. The present chapter summarizes work from this laboratory on the preparation of lipid vesicles that release their contents in response to specific chemical or ...
Tirrell, David A.
core  

Conversion of phosphatidylethanolamine to phosphatidylcholine in rat brain by the methylation pathway [PDF]

, 1979
Rita Mozzi, Giuseppe Porcellati
openalex   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

X-Ray Kinematography of Temperature-Jump Relaxation Probes the Elastic Properties of Fluid Bilayers [PDF]

arXiv, 2000
The response kinetics of liquid crystalline phosphatidylcholine bilayer stacks to rapid, IR-laser induced temperature jumps has been studied by millisecond time-resolved x-ray diffraction. The system reacts on the fast temperature change by a discrete bilayer compression normal to its surface and a lateral bilayer expansion.
arxiv  

Exploring the Potential of Liposomal Delivery of Naringenin and Berberine for Browning Adipose Tissue and Obesity Management

European Journal of Lipid Science and Technology, EarlyView.
Biocompatible and biodegradable liposomes were developed to encapsulate naringenin (N) and berberine (B), enhancing their stability and bioavailability. Their effects on thermogenesis and browning in 3T3‐L1 preadipocyte cells compared to their free forms were investigated.
Elif Didem Örs Demet, Kübra Uçar Baş, Aslıhan Alpaslan, Dilem Tuğal Aslan, Tuba Reçber, Tuğba Gülsün, Mustafa Çelebier, Zeynep Göktaş   +7 more
wiley   +1 more source

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication[S]

Journal of Lipid Research, 2014
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking.
Lukas Bahati Tanner, Charmaine Chng, Xue Li Guan, Zhengdeng Lei, Steven G. Rozen, Markus R. Wenk   +5 more
doaj  

The effect of fasting and refeeding on the composition and synthesis of triacylglycerols, phosphatidylcholines, and phosphatidylethanolamines in rat liver [PDF]

, 1979
J.E.M. Groener, W. R. Klein, L.M.G. Van Golde   +2 more
openalex   +1 more source