Results 141 to 150 of about 17,880 (307)

Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis.

, 2012
BACKGROUNDCurrent non-invasive diagnostic methods for endometriosis lack sensitivity and specificity. In search for new diagnostic biomarkers for ovarian endometriosis, we used a hypothesis-generating targeted metabolomics approach.METHODSIn a case ...
Prehn, C., Rizner, T.L., Osredkar, J., Adamski, J., Hevir, N., Ribič-Pucelj, M., Vouk, K., Haarpaintner, G., Scherb, H., Möller, G.   +9 more
core   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Examining Phosphatidylethanol (PEth) Formation Rates Within and Between Subjects in Ex Vivo Whole Blood

Drug Testing and Analysis, EarlyView.
PEth formation rate increased with increasing ethanol concentration with variability between participants but was mostly consistent within‐subject. No relationship was observed between phosphatidylcholine concentrations and PEth formation rates. PEth concentrations should be used to monitor an individual's ethanol use over time, rather than compared ...
Haidyn G. Stark, Jesus J. Sanchez, Nathalie Hill‐Kapturczak, John D. Roache, Brett C. Ginsburg   +4 more
wiley   +1 more source

Plasma lipidomics in early APP/PS1 female mouse model and its relationship with brain: Is it affected by the estrous cycle?

Alzheimer’s Research & Therapy
Background Alzheimer's disease (AD) is the most prevalent dementia, showing higher incidence in women. Besides, lipids play an essential role in brain, and they could be dysregulated in neurodegeneration.
Laura Ferré-González, Ángel Balaguer, Marta Roca, Artemis Ftara, Ana Lloret, Consuelo Cháfer-Pericás   +5 more
doaj   +1 more source

Quantification des phosphatidylcholines disaturées pulmonaires foetaux murins et dimorphisme sexuel

, 2011
Chez l'humain et la souris, les androgènes retardent la montée de la production de surfactant pulmonaire chez le mâle. L'objectif de ce projet mené chez la souris est de déterminer les moments gestationnels exacts où la production de surfactant augmente ...
Gérard Hudon, Marie-Christine
core  

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Phosphatidylcholine

Biophysical Journal, 1992
Thewalt, Jenifer L., Bloom, Myer
openaire   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source