Results 121 to 130 of about 15,382 (263)

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan. [PDF]

Aging Cell
Bene MR, Zhang C, Westbrook R, Gabrawy M, Marx R, Wu Y, Khadeer M, Ubaida-Mohien C, Ferrucci L, Moaddel R, Le A, Walston JD, Lee JL, Abadir PM.   +13 more
europepmc   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Oxidized Phosphatidylcholines Regulate Secretory Phospholipase A₂ Through Membrane Nanodomain Remodeling. [PDF]

Molecules
Yordanova V, Hazarosova R, Vitkova V, Angelova R, Nikolova B, Elenkova A, Momchilova A, Staneva G.   +7 more
europepmc   +1 more source

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Comprehensive first-trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology. [PDF]

Front Mol Biosci
Mojsak P, Godlewski A, Sołowiej K, Kulczynska-Przybik A, Chmielewska S, Mroczko B, Szelachowska M, Krętowski A, Ciborowski M.   +8 more
europepmc   +1 more source

Physical stability of RNA–lipid nanoparticles under agitation, freeze–thaw and accelerated stability testing

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras, Leah Wright, Robert J Falconer   +2 more
wiley   +1 more source

The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study. [PDF]

Front Mol Biosci
Reis A, Sohrabi Y, Diaz-Sanchez L, Dias Araújo AR, Leffers M, Antonny B, Rudnitskaya A, Vitorino R, Dias IHK.   +8 more
europepmc   +1 more source

Study on the structure of phosphatidylcholine-pyrazole and phosphatidylcholine-pyridine complexes [PDF]

Biopolymers and Cell, 2002
R. S. Nasibullin, D. I. Kosareva, M. A. Serebrenik, L. V. Spirikhin   +3 more
openaire   +1 more source

Comparison of methods for defatted human milk and nutrient composition: An experimental study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Human milk is considered the gold standard for infant nutrition; however, it is often discontinued in chylothorax and severe very long‐chain acyl‐CoA dehydrogenase (VLCAD) deficiency. As an alternative to complete human milk restriction, defatted human milk may be fed, though it may not fully support optimal infant growth and ...
Kristin Cheng, Gina O'Toole, Stephanie Chang, Richard Chang, John Miklavcic   +4 more
wiley   +1 more source