Results 121 to 130 of about 19,173 (307)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Azide-Modified Membrane Lipids: Miscibility with Saturated Phosphatidylcholines

, 2019
In this study, we describe the miscibility of four azide-modified membrane phospholipids (azidolipids) with conventional phospholipids. The azidolipids bear an azide group at different positions of the sn-1 or sn-2 alkyl chain and they further differ in ...
Simon Drescher (526349), Christian Schwieger (1782379), Christian Schwieger, Annette Meister, Gerd Hause, Vasil M. Garamus, Sindy Müller, Kai Gruhle (4016627), Vasil M. Garamus (1827853), Gerd Hause (236755), Annette Meister (1285317), Simon Drescher, Sindy Müller (5018090), Kai Gruhle   +13 more
core   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Genetic causality of lipidomic and immune cell profiles in ischemic stroke

Frontiers in Neurology
BackgroundIschemic stroke (IS) is a global health issue linked to lipid metabolism and immune cell responses. This study uses Mendelian randomization (MR) to identify genetic risk factors for IS subtypes using comprehensive genetic data from lipidomic ...
Haohao Chen, Haohao Chen, Zequn Zheng, Zequn Zheng, Xiaorui Cai, Shunxian Li, Manli Chen, Jiaming Wu, Wenzhen He, Fenfei Gao   +9 more
doaj   +1 more source

Conformation of the choline chain of phosphatidylcholines - A FTIR study of the symmetric C-N (CH

, 2017
Infrared spectra of phosphatidylcholines in various forms of aggregation (multilamellar films, liposomes, unilamellar vesicles, micelles) exhibit a composite band in the 931-904cm-1 region which is ascribed to the C-N(CH3)3 stretching of the choline ...
J Grdadolnik, D Hadži
core   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows

Animal
Feeding very-long-chain omega-3 (VLC n-3) fatty acids (FA), which are found in fish oil, may have beneficial effects on health, fertility, and milk production in the dairy cow.
J.E. Rico, V. Sáinz de la Maza-Escolà, N.D. Senevirathne, P. Deme, N.J. Haughey, R. Gervais, J.W. McFadden   +6 more
doaj   +1 more source

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

Nature Communications, 2018
Methyl metabolites in the one-carbon cycle, such as phosphatidylcholines and S-adenosylmethionine, play a role in hepatic triglyceride regulation. Here Kim et al.
Young-Chae Kim, Sunmi Seok, Sangwon Byun, Bo Kong, Yang Zhang, Grace Guo, Wen Xie, Jian Ma, Byron Kemper, Jongsook Kim Kemper   +9 more
doaj   +1 more source

Uncovering the potential for oxidized phosphatidylcholines as unique drivers of asthma pathobiology

Asthma pathobiology is characterized by persistent oxidative stress in the lungs that causes oxidative damage in the cell membrane and extracellular phospholipids.
Vaghasiya, Jigneshkumar
core  

Fraction of saturated phosphatidylcholines in undifferentiated (DMSCs) and differentiated (ATII-LCs) decidua-derived mesenchimal cells in comparison with primary ATII pneumocytes.

, 2014
mean values ± s.d. have been calculated with respect to total PC.Fraction of saturated phosphatidylcholines in undifferentiated (DMSCs) and differentiated (ATII-LCs) decidua-derived mesenchimal cells in comparison with primary ATII pneumocytes.
Ana I. Flores (644871), Thomas Haller (247763), Jesús Pérez-Gil (152437), Paz de la Torre (644869), Jesús Grande (644870), Alejandro Cerrada (644868)   +5 more
core   +1 more source