Results 101 to 110 of about 19,173 (307)

Enigmatic thermotropic phase behavior of highly asymmetric mixed-chain phosphatidylcholines that form mixed-interdigitated gel phases [PDF]

, 1994
Twelve saturated mixed-chain phosphatidylcholines have been identified for which the thermotropic phase behavior observed upon cooling from the L alpha phase is dependent upon the thermal history of the sample in the gel phase.
Osterberg, F., Gruner, S.M., Lewis, R.N., McElhaney, R.N.   +3 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

The factors and protocols that influence, accuracy, precision and uncertainty of accurate mass measurements by FT-ICR ms to validate the assignment of elemental composition

, 2009
The need for very accurate mass measurements of compounds is becoming more demanding with the expansion of the number of compounds in need of correct identification and with the limits of elemental analysis; a fast, robust analytical solution is sought ...
Wronska, Louisa Victoria May
core   +1 more source

Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry

, 2019
The analysis of lipid droplets (LDs) by mass spectrometry at the single LD level is still an analytical challenge. In this work, we developed a novel technique termed in-tip solvent microextraction mass spectrometry for the separation and profiling of ...
Zhen Chen (129176), Zhen Chen, Yue Wu (1262184), Takayuki Tsukui, Hitoshi Chiba, Xiaoxiao Ma (586248), Hitoshi Chiba (119750), Yue Wu, Shu-Ping Hui, Takayuki Tsukui (6412235), Xinrong Zhang, Yaoyao Zhao (1481812), Yaoyao Zhao, Xiaoxiao Ma, Shu-Ping Hui (4429231), Xinrong Zhang (1347924)   +15 more
core   +1 more source

Light‐Controlled Conductive Molecular Wire in an Artificial Lipid Membrane

Advanced Science, EarlyView.
A photochromic azobenzene derivative is shown to produce a unique photoelectric response when embedded in artificial lipid membranes. In its trans state, it forms conductive “molecular wires” that enhance membrane conductivity in the dark. Light‐induced cis isomerization suppresses this effect, showing that short‐chain molecules can modulate membrane ...
Ilaria Cardace, Lorenzo Dominici, Adriano Cola, Antonio Fieramosca, Vincenzo Ardizzone, Agostina Lina Capodilupo, Bruno Rizzuti, Milena De Giorgi, Dario Ballarini, Giuseppe Gigli, Daniele Sanvitto, Luisa De Marco   +11 more
wiley   +1 more source

Platelet activating factor and lyso-phosphatidylcholines from strawberry

, 1996
Lipids from strawberry fruits, leaves, achenes and pollen were separated into classes by TLC, purified by HPLC and tested for biological activity. A lipid fraction from fruits with the same chromatographic behaviour as authentic platelet activating ...
Mavri-Vavayanni, M., Weintraub, S.T., Calligerou, M., Siafaka-Kapadai, A., Galanopoulou, D.   +4 more
core   +2 more sources

Phase behaviour of aqueous systems of enzymatically modified phosphatidylcholines with one hexadecyl and one hexyl or octyl chain

, 1993
Phosphatidylcholines composed of a hexadecyl chain in the 2-position and a hexyl or octyl chain in the l-position (C6C16PC or C8C16PC) were prepared from dipalmitoylphosphatidylcholine by lipase-catalyzed transesterification; the aqueous phase properties
Svensson, I., Miesiz, Y., Larsson, K., Mattiasson, B., Adlercreutz, P.   +4 more
core   +1 more source

A Macroscopic Description of Lipid Bilayer Phase Transitions of Mixed-Chain Phosphatidylcholines: Chain-Length and Chain-Asymmetry Dependence [PDF]

, 2001
A macroscopic model is presented to quantitatively describe lipid bilayer gel to fluid phase transitions. In this model, the Gibbs potential of the lipid bilayer is expressed in terms of a single order parameter q, the average chain orientational order ...
Johnson, Michael L., Chen, Lubin, Biltonen, Rodney L.   +2 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates

Angewandte Chemie, EarlyView.
An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho, Cindy Y. Jao, Zijun Xia, Brittany M. White‐Mathieu, Adrian Salic, Jeremy M. Baskin   +5 more
wiley   +2 more sources