Results 111 to 120 of about 80,395 (343)

Molecular Weight Dependence of Polymersome Membrane Elasticity and Stability

, 2001
Vesicles prepared in water from a series of diblock copolymers and termed "polymersomes" are physically characterized. With increasing molecular weight $\bar{M}_n$, the hydrophobic core thickness $d$ for the self-assembled bilayers of polyethyleneoxide -
Bates, Frank S., Bermudez, Harry, Brannan, Aaron K., Discher, Dennis E., Hammer, Daniel A.   +4 more
core   +3 more sources

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids

Beilstein Journal of Organic Chemistry, 2017
In the present work, we describe the synthesis of a single-chain, phenylene-modified bolalipid with two phosphocholine headgroups, PC-C18pPhC18-PC, using a Sonogashira cross-coupling reaction as a key step.
Simon Drescher, Vasil M. Garamus, Christopher J. Garvey, Annette Meister, Alfred Blume   +4 more
doaj   +1 more source

Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation Published, JLR Papers in Press, August 16, 2003. DOI 10.1194/jlr.D300020-JLR200

Journal of Lipid Research, 2003
The molecular composition of phosphatidylcholines (PCs) in total lipid extracts was characterized by a combination of multiple precursor ion scanning on a hybrid quadrupole time-of-flight mass spectrometer and MS3 fragmentation on an ion trap mass ...
K. Ekroos, Christer S. Ejsing, U. Bahr, M. Karas, K. Simons, A. Shevchenko   +5 more
semanticscholar   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging

Angewandte Chemie, EarlyView.
Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas, Amy L. Parkhurst, Ming‐Fo Hsu, Christopher Hou, Fawaz G. Haj, Elizabeth K. Neumann   +5 more
wiley   +2 more sources

Exclusion of maltodextrins from phosphatidylcholine multilayers during dehydration: effects on membrane phase behaviour [PDF]

, 2003
The effect of increasing solute size on phosphatidylcholine phase behaviour at a range of hydrations was investigated using differential scanning calorimetry.
Bryant, G, Koster, K, Maddocks, K
core  

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Generation and quality control of lipidomics data for the alzheimers disease neuroimaging initiative cohort. [PDF]

, 2018
Alzheimers disease (AD) is a major public health priority with a large socioeconomic burden and complex etiology. The Alzheimer Disease Metabolomics Consortium (ADMC) and the Alzheimer Disease Neuroimaging Initiative (ADNI) aim to gain new biological ...
AA Willette, B De Strooper, CA McLean, CC Liu, CR Jack Jr., CS McCoin, DA Butterfield, F Picconi, F Zhu, G McKhann, G Verdile, H Tsugawa, J Fahrmann, J Gotz, JM Weir, KH Ashe, KP Ng, L St John-Williams, MG Spillantini, MR Wenk, MR Wenk, MW Weiner, MW Weiner, MW Wong, O Quehenberger, P Edison, P Proitsi, P Proitsi, R Kaddurah-Daouk, R Ossenkoppele, RC Petersen, S Kullmann, SG Mueller, SM de la Monte, SN Jackson, T Cajka, T Cajka, T Cajka, T Cajka, T Kind, TJ Montine, X Han, Y Huang   +42 more
core   +2 more sources

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source