Results 231 to 240 of about 71,224 (296)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Revisiting the Link Between Meat Intake and the Risk of Type 2 Diabetes in American Indians: Insights Based on Lipidomic Profiles. [PDF]

Diabetes Care
Zhang C, Wang B.
europepmc   +1 more source

Proton translocation by a native and subunit III-depleted cytochrome c oxidase reconstituted into phospholipid vesicles. Use of fluorescein-phosphatidylethanolamine as an intravesicular pH indicator.

, 1985
Marcus Thelen, Paul O’Shea, Goffredo Petrone, Angelo Azzi   +3 more
openalex   +1 more source

Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Women with overweight or obesity follow intended isocaloric early and late time‐restricted eating (TRE) in a crossover trial. Shotgun plasma lipidomics reveals no significant differences between interventions, but identify pronounced lipid changes—including reductions in ceramides and phosphatidylcholines—within the early TRE.
Kristof Szekely, Mathias J. Gerl, Beeke Peters, Julia Schwarz, Bettina Schuppelius, Markus Damm, Jorge R. Soliz‐Rueda, Ratika Sehgal, Michail Lazaratos, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer, Annette Schürmann, Achim Kramer, Andreas Michalsen, Olga Pivovarova‐Ramich   +15 more
wiley   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, Volume 13, Issue 5, 27 January 2026.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Potential Metabolic Markers in the Tongue Coating of Chronic Gastritis Patients for Distinguishing Between Cold Dampness Pattern and Damp Heat Pattern in Traditional Chinese Medicine Diagnosis. [PDF]

J Inflamm Res
Yuan S, Zhang R, Zhu Z, Zhou X, Zhang H, Li X, Hao Y.   +6 more
europepmc   +1 more source

Diversity and Ecological Potentials of Marine Viruses Inhabiting Continental Shelf Seas

Advanced Science, Volume 13, Issue 1, 5 January 2026.
To the best of the knowledge, this study provides the largest viral genome dataset from a continental shelf sea. It reveals that over half of vOTUs are novel, highlighting the remarkable viral novelty in the eastern continental shelf seas of China (ECSSC).
Xiaoyue Guo, Yantao Liang, Chen Gao, Hao Yu, Meiwen Wang, Hongbing Shao, Yeqing Yang, David Paez‐Espino, Andrew McMinn, Min Wang   +9 more
wiley   +1 more source

Glycerophospholipid fatty acid remodeling optimizes lipid nutrition and volatile organic compound composition in freshwater fish with linolenic acid intervention. [PDF]

Food Chem X
He Z, Wang J, Wei Y, Yan X, Li Y, Nie G, Xie D.   +6 more
europepmc   +1 more source