Results 241 to 250 of about 71,224 (296)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Quantifying the Activation Barrier for Phospholipid Monolayer Fusion Governing Lipid Droplet Coalescence. [PDF]

Int J Mol Sci
Molotkovsky RJ, Denieva ZG, Senchikhin IN, Urodkova EK, Konarev PV, Peters GS, Galimzyanov TR, Pavlov RV, Bashkirov PV.   +8 more
europepmc   +1 more source

Advances in Synchrotron Radiation‐Based Vacuum‐Ultraviolet Circular Dichroism for Biomolecular Structural Analysis

Chemistry – An Asian Journal, Volume 21, Issue 2, 28 January 2026.
Vacuum‐ultraviolet circular dichroism spectroscopy using synchrotron radiation is operated at the Research Institute for Synchrotron Radiation Science (HiSOR), Hiroshima University. By combining the circular dichroism technique with bioinformatics, molecular dynamics, and linear dichroism, the spectral analysis methods have been advanced, enabling ...
Koichi Matsuo, Satoshi Hashimoto, Ryota Imaura, Mohamed I. A. Ibrahim   +3 more
wiley   +1 more source

Corrigendum: LC-MS/MS untargeted lipidomics uncovers placenta lipid signatures from intrahepatic cholestasis of pregnancy

Frontiers in Physiology
Liling Xiong, Mi Tang, Hong Liu, Jianghui Cai, Ying Jin, Cheng Huang, Shasha Xing, Xiao Yang   +7 more
doaj   +1 more source

Maternal red blood cell folate metabolites were dynamically associated with neonatal amino acids and acylcarnitines in heel blood: a prospective cohort study. [PDF]

Nutr Metab (Lond)
Yang R, Zheng W, Lu Y, Zhang Y, Zhang L, Yan X, Chen T, Wang Z, Shi X, Kong Y, Li G.   +10 more
europepmc   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

BioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige, Yves Mély, Toshihide Kobayashi   +2 more
wiley   +1 more source

Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis. [PDF]

Medicine (Baltimore)
Li W, Gan J, Jiao J, Li J, Xu L, Li D, Geng Y, Shen M, Liang J, Lin H, Zhong L.   +10 more
europepmc   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases. [PDF]

Mol Metab
Taradeh M, Hardy LM, Dahik VD, Lhomme M, Wang H, Reydellet C, Materne C, Kc P, Bun E, Clemessy M, Pais-De-Barros JP, Galier S, Frisdal E, Durand H, Ponnaiah M, El Khoury P, Villard EF, Lesnik P, Gallo A, Kappeler L, Giral P, Bruckert E, Masson D, Guerin M, Kontush A, Guillas I, Le Goff W.   +26 more
europepmc   +1 more source