Results 271 to 280 of about 106,919 (341)

A Global Metabolomic and Lipidomic Landscape of Human Plasma Across the Lifespan

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Liu et al. provide a comprehensive analysis of dynamic plasma metabolomic and lipidomic changes in humans across the lifespan, identifying age‐specific metabolic trajectories and developing a metabolite‐based aging clock, offering insights into metabolic reprogramming and potential biomarkers for aging‐related health interventions.
Xinru Liu   +6 more
wiley   +1 more source

A Simplified Methodology for Solvent Screening in Selective Extraction of Lipids from Microalgae Based on Hansen Solubility Parameters. [PDF]

open access: yesMolecules
Tsioptsias C   +8 more
europepmc   +1 more source

The 3xTg‐AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex‐Specific Neuropathological and Behavioral Phenotypes

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
This study found that 3xTg‐AD mice exhibited lifelong reductions in circulating choline. Female 3xTg‐AD mice showed greater AD‐like pathology, whereas males displayed higher mortality, impulsivity, and water‐seeking behavior. These sex‐specific differences suggest distinct metabolic and behavioral vulnerabilities contributing to AD progression in this ...
Jessica M. Judd   +5 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

open access: yesJournal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy