Multi-omics analysis reveals metabolic regulation of phosphatidylcholine, triglycerides, phosphatidylethanolamine, and cardiolipin metabolism in mouse liver with metabolic dysfunction-associated steatotic liver disease. [PDF]
Liang H, Song K.
europepmc +1 more source
A Global Metabolomic and Lipidomic Landscape of Human Plasma Across the Lifespan
Liu et al. provide a comprehensive analysis of dynamic plasma metabolomic and lipidomic changes in humans across the lifespan, identifying age‐specific metabolic trajectories and developing a metabolite‐based aging clock, offering insights into metabolic reprogramming and potential biomarkers for aging‐related health interventions.
Xinru Liu +6 more
wiley +1 more source
A Simplified Methodology for Solvent Screening in Selective Extraction of Lipids from Microalgae Based on Hansen Solubility Parameters. [PDF]
Tsioptsias C +8 more
europepmc +1 more source
This study found that 3xTg‐AD mice exhibited lifelong reductions in circulating choline. Female 3xTg‐AD mice showed greater AD‐like pathology, whereas males displayed higher mortality, impulsivity, and water‐seeking behavior. These sex‐specific differences suggest distinct metabolic and behavioral vulnerabilities contributing to AD progression in this ...
Jessica M. Judd +5 more
wiley +1 more source
UHPLC-MS/MS-based plasma untargeted lipidomic analysis in patients with diabetes mellitus combined with hyperuricemia. [PDF]
Xu Y +6 more
europepmc +1 more source
Rapid appearance of newly synthesized phosphatidylethanolamine at the plasma membrane.
Richard G. Sleight, Richard E. Pagano
openalex +1 more source
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli +12 more
wiley +1 more source

