Results 51 to 60 of about 72,154 (294)
UV analysis of Amadori-glycated phosphatidylethanolamine in foods and biological samples
Journal of Lipid Research, 2002 Maillard reactions are among the most important of the chemical and oxidative changes occurring in food and biological samples that contribute to food deterioration and to the pathophysiology of human disease.
Jeong-Ho Oak +2 more
doaj +1 more source
pdx1 Knockout Leads to a Diabetic Nephropathy– Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage [PDF]
, 2022 Lucas M. Wiggenhauser +13 more
openalex +1 more source
Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response
Advanced Science, EarlyView.This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai +7 more
wiley +1 more source
Physiological consequences of disruption of mammalian phospholipid biosynthetic genes
Journal of Lipid Research, 2009 By 1959, Eugene Kennedy and coworkers had outlined most pathways of phospholipid biosynthesis. In the next four decades, the emphasis was on enzymology and regulation of these pathways.
Dennis E. Vance, Jean E. Vance
doaj +1 more source
Advanced Science, EarlyView.A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du +17 more
wiley +1 more source
Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation [PDF]
Biochemistry, 2012 The toxicity of amyloid-forming peptides has been hypothesized to reside in the ability of protein oligomers to interact with and disrupt the cell membrane. Much of the evidence for this hypothesis comes from in vitro experiments using model membranes.
Sciacca, Michele F.M. +3 more
openaire +3 more sources
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source
Intracellular sites of lipid synthesis and the biogenesis of mitochondria
Journal of Lipid Research, 1972 Experimental data are presented on the intracellular localization in rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol.
Edward A. Dennis, Eugene P. Kennedy
doaj +1 more source
Advanced Science, EarlyView.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source