Results 161 to 170 of about 8,868 (194)

Expression of Phosphatidylethanolamine N-Methyltransferase in Human Hepatocellular Carcinomas

Oncology, 2003
<i>Objective:</i> Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Our previous reports implicated PEMT in the regulation of hepatocyte growth and transformation.
L. TESSITORE, B. MARENGO, D. E. VANCE, PAPOTTI, Mauro Giulio, MUSSA, Antonio, M. G. DAIDONE, A. COSTA   +6 more
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Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase

Biochemical Journal, 2010
The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). In the present study, to compare the functions of the two isoforms of PEMT, we established HEK (human embryonic kidney)-293 cell
Shin-ya, Morita, Atsuko, Takeuchi, Shuji, Kitagawa   +2 more
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Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice

Molecular Brain Research, 2005
Choline is derived from the diet as well as from de novo methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Pemt knockout mice have no endogenous synthesis of choline molecules. We previously reported that these mice have excess S-adenosylmethionine and hypermethylated DNA in brain, as well as ...
Xiaonan, Zhu, Steven H, Zeisel
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Surface membrane-associated phosphatidylethanolamine N-methyltransferase activity in L-929 cells

Archives of Biochemistry and Biophysics, 1983
L-929 cell surface membranes were incubated with S-adenosyl-L-[methyl-3H]-methionine and found to contain phosphatidylethanolamine: S-adenosylmethionine N-methyltransferase (phosphatidylethanolamine N-methyltransferase) activity. The enzyme or combination of enzymes responsible for this activity methylated endogenous phosphatidylethanolamine and its ...
L C, Garg, J C, Brown
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Physiological function of phosphatidylethanolamine N-methyltransferase

2015
Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine (PC) biosynthesis via three sequential methylations of phosphatidylethanolamine (PE). PEMT is also expressed in white adipose tissue (WAT).
openaire   +1 more source

Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina

Experimental Eye Research, 1995
Phosphatidylcholine (PC) can be synthesized in isolated rod outer segments from bovine retina by successive transfer of methyl groups from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine (PE), with the intermediate formation of phosphatidyl-N-monomethylethanolamine (PMME) and phosphatidyl-N,N-dimethylethanolamine (PDME). This reaction is time-
M E, Roque, N M, Giusto
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PhosphatidylethanolamineN-Methyltransferase and Regulation of Homocysteine

Nutrition Reviews, 2006
Homocysteine is a non-protein, sulfur-containing amino acid derived from methionine metabolism and S-adenosylmethionine (SAM)-dependent transmethylation. Elevations in plasma homocysteine have been associated with increased risk of cardiovascular disease, atherosclerosis, birth defects, Alzheimer's disease, and osteoporosis.
Cara S, Hartz, Kevin L, Schalinske
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Sexually Dimorphic Activation of Liver and Brain Phosphatidylethanolamine N-Methyltransferase by Dietary Choline Deficiency

Neurochemical Research, 1998
Phosphatidylethanolamine N-methyltransferase (PEMT) activity was measured by a radioenzymatic assay in homogenates of brain and liver obtained from Sprague Dawley rats fed a choline-free or control (0.3 g/kg of choline chloride) diet for seven days. Choline deficiency increased PEMT activity in the liver of male rats by 34% but had no effect on hepatic
P I, Johnson, J K, Blusztajn
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Rat hepatic phosphatidylethanolamine N-methyltransferase : enzyme purification and characterization

2010
Phosphatidylethanolamine (PE) N-methyltransferase catalyzes the stepwise transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) to the amino headgroup of PE. Successive methylation results in the formation of the two intermediates, phosphatidyl-N-monomethylethanolamine (PMME) and phosphatidyl-N, N-dimethylethanolamine (PDME), and the final ...
openaire   +1 more source

Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.

European journal of medical research, 1998
In the process of investigating basic questions about the function of the enzyme phosphatidyl-ethanolamine N-methyltransferase (PEMT), we have made several unexpected findings. PEMT catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in hepatocytes.
openaire   +1 more source