Pemt Deficiency Ameliorates Endoplasmic Reticulum Stress in Diabetic Nephropathy [PDF]
PLoS ONE, 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.
Atsuko Nakatsuka +2 more
exaly +25 more sources
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
Molecular Metabolism, 2020 Objective: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis.
Jordan M Johnson +2 more
exaly +6 more sources
Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease [PDF]
Advanced ScienceSerine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one‐carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one‐carbon metabolism is reported in both Parkinson's disease (PD) patients and animal models ...
Yue‐Han Chen +17 more
doaj +3 more sources
Diet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD [PDF]
Nature CommunicationsHigh-fat diet (HFD) is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet the molecular pathways that connect dietary fats to liver dysfunction remain unclear.
Mengjie Li +10 more
doaj +2 more sources
HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation [PDF]
Cell Death DiscoveryIn mammalian reproduction, a significant proportion of embryos fail to implant despite a receptive uterus, suggesting that defects in epithelial remodeling at the embryo–uterine interface contribute to implantation failure.
Nancy Ashary +11 more
doaj +2 more sources
Gain of function p53 mutant R273H confers distinct methylation profiles and consequent YAP/TAZ signaling mediated activation of partial or full EMT states to colon tumours [PDF]
Epigenetics & ChromatinBackground Mutations in tumour suppressor p53 are frequently implied in aggressive progression and metastasis in colorectal cancer. But the distinct phenotypes exhibited by site-specific mutations of p53 are not well elucidated.
Harsha Rani +3 more
doaj +2 more sources
TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids [PDF]
OncogenesisCancer cells infiltrating surrounding tissue frequently undergo partial epithelial-mesenchymal transitions (pEMT) and employ a collective mode of invasion. How these phenotypic traits are regulated and interconnected remains underexplored.
Yu-Hsiang Teng +9 more
doaj +2 more sources
HDAC11 promotes renal fibrosis by induing partial epithelial-mesenchymal transition and G2/M phase arrest in renal epithelial cells [PDF]
Molecular MedicineBackground Histone deacetylase 11 (HDAC11) is the sole member of class IV HDACs, implicated in tumor growth, immune regulation, and oxidative stress injury. Its specific role in renal fibrosis and underlying mechanisms remains unclear. Methods The global
Yingjie Guan +5 more
doaj +2 more sources
TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis [PDF]
Molecular Therapy: Nucleic AcidsEpithelial-mesenchymal transition (EMT) is associated with retinal pigment epithelium (RPE) dysfunction in degenerative retinal diseases. However, the role of partial EMT (pEMT), a hybrid state exhibiting both epithelial and mesenchymal markers, remains ...
Jing Li +9 more
doaj +2 more sources
Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling [PDF]
Clinical EpigeneticsBackground Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3), has been implicated in promoting renal fibrogenesis.
Chao Yu +8 more
doaj +2 more sources