Results 1 to 10 of about 8,868 (194)

Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice [PDF]

Biomolecules, 2022
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosynthesis of PC,
Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujić, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl   +11 more
doaj   +5 more sources

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. [PDF]

PLoS ONE, 2015
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood.
Tommy Pacana, Sophie Cazanave, Aurora Verdianelli, Vaishali Patel, Hae-Ki Min, Faridoddin Mirshahi, Eoin Quinlivan, Arun J Sanyal   +7 more
doaj   +11 more sources

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase [PDF]

Journal of Lipid Research, 2017
Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which is mainly ...
Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E. Vance, René L. Jacobs   +6 more
doaj   +2 more sources

LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk. [PDF]

Br J Cancer, 2014
BACKGROUND: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation level and bladder cancer risk
Tajuddin SM, Amaral AF, Fernández AF, Chanock S, Silverman DT, Tardón A, Carrato A, García-Closas M, Jackson BP, Toraño EG, Márquez M, Urdinguio RG, García-Closas R, Rothman N, Kogevinas M, Real FX, Fraga MF, Malats N, Spanish Bladder Cancer/EPICURO Study investigators.   +18 more
europepmc   +5 more sources

Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy. [PDF]

PLoS ONE, 2014
Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver.
Mayu Watanabe, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Chigusa Higuchi, Akihiro Katayama, Sanae Teshigawara, Jun Eguchi, Daisuke Ogawa, Eijiro Watanabe, Jun Wada, Hirofumi Makino   +12 more
doaj   +5 more sources

Characterization of the murine phosphatidylethanolamine N-methyltransferase-2 gene

Journal of Lipid Research, 1996
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations.
C J Walkey, Z Cui, L B Agellon, D E Vance   +3 more
doaj   +3 more sources

Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males [PDF]

Frontiers in Nutrition
BackgroundResponsiveness to nutrients can be determined by many types of variations, such as single-nucleotide polymorphisms (SNPs). Choline is an essential nutrient critical for proper organ function and exists in different forms, such as free choline ...
Nisa Butt, Jianzhang Dong, Gia V. Shelp, Elizabeth M. Poole, Justine R. Keathley, Marica Bakovic, Clara E. Cho   +6 more
doaj   +2 more sources

Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]

FASEB J
Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S.   +6 more
europepmc   +2 more sources

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer [PDF]

, 2014
The current view of cancer progression highlights that cancer cells must undergo through a post-translational regulation and metabolic reprogramming to progress in an unfriendly environment.
Aspichueta, Patricia, Barbier Torres, Lucía, Beraza, Naiara, Boix, Loreto, Bruix, Jordi, Buqué, Xabier, Cano, Ainara, Castro, Azucena, Delgado, Teresa C, Fernández Domínguez, Itziar, Fernández Ramos, David, Fernández Tussy, Pablo, García Rodríguez, Juan L, Gutiérrez de Juan, Virginia, Lopitz Otsoa, Fernando, Lu, Shelly C, Martínez Chantar, María L., Mato, José M, Varela Rey, Marta, VILLA, Erica, Xirodimas, Dimitris, Zubiete Franco, Imanol   +21 more
core   +9 more sources

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources