Results 11 to 20 of about 8,868 (194)

Physiological roles of phosphatidylethanolamine N-methyltransferase [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). This 22.3 kDa protein is localized to the endoplasmic reticulum and mitochondria associated membranes of liver.
Vance, Dennis E.
core   +6 more sources

Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020
Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). It has been previously reported that, unexpectedly, PEMT deficiency protected from high-fat diet (HFD)-induced obesity and insulin resistance, pointing to a possible role of this enzyme in ...
Natalia, Presa, Asier, Dominguez-Herrera, Jelske N, van der Veen, Dennis E, Vance, Antonio, Gómez-Muñoz   +4 more
openaire   +4 more sources

The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019
Background. Acute pancreatitis is considered to be an important issue in modern medicine. The phosphatidylethanolamine-N-methyltransferase enzyme plays a significant role in the regulation of lipid metabolism by catalyzing the process of methylation of ...
T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov   +5 more
doaj   +3 more sources

Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase.

Journal of Lipid Research, 1993
The metabolism of the molecular species of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) derived from [3H]ethanolamine has been studied in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine-N-methyltransferase (PEMT ...
RW Samborski, ND Ridgway, DE Vance
doaj   +3 more sources

Phosphatidylethanolamine N-methyltransferase: from Functions to Diseases. [PDF]

Aging Dis, 2023
Locating on endoplasmic reticulum and mitochondria associated membrane, Phosphatidylethanolamine N-methyltransferase (PEMT), catalyzes phosphatidylethanolamine methylation to phosphatidylcholine. As the only endogenous pathway for choline biosynthesis in mammals, the dysregulation of PEMT can lead to imbalance of phospholipid metabolism.
Li J, Xin Y, Li J, Chen H, Li H.
europepmc   +3 more sources

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis. [PDF]

Sci Rep, 2016
AbstractAlthough obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been recognized. Here, we report that the insufficiency of phosphatidylethanolamine N-methyltransferase (PEMT) is a risk for the lean NASH. The Pemt−/− mice fed high fat-high sucrose (HFHS) diet
Nakatsuka A, Matsuyama M, Yamaguchi S, Katayama A, Eguchi J, Murakami K, Teshigawara S, Ogawa D, Wada N, Yasunaka T, Ikeda F, Takaki A, Watanabe E, Wada J.   +13 more
europepmc   +10 more sources

Membrane Topography of Human Phosphatidylethanolamine N-Methyltransferase [PDF]

Journal of Biological Chemistry, 2003
In liver, phosphatidylethanolamine is converted to phosphatidylcholine through a series of three sequential methylation reactions. Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes each transmethylation reaction, and S-adenosylmethionine is the methyl group donor.
David J, Shields, Richard, Lehner, Luis B, Agellon, Dennis E, Vance   +3 more
openaire   +2 more sources

Kinetic mechanism of phosphatidylethanolamine N-methyltransferase.

Journal of Biological Chemistry, 1988
We have investigated the kinetic mechanism of phosphatidylethanolamine (PE) N-methyltransferase purified from rat liver using PE, phosphatidyl-N-monomethylethanolamine (PMME), and phosphatidyl-N,N-dimethylethanolamine (PDME) as substrates. We previously reported (Ridgway, N. D., and Vance, D. E. (1987) J. Biol. Chem.
N D, Ridgway, D E, Vance
  +7 more sources

A role for Sp1 in transcriptional regulation of phosphatidylethanolamine N-methyltransferase in liver and 3T3-L1 adipocytes. [PDF]

J Biol Chem, 2010
Cole LK, Vance DE.
europepmc   +2 more sources

Thematic Review Series: Glycerolipids. Phosphatidylcholine and choline homeostasis

Journal of Lipid Research, 2008
Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline. The main fate of
Zhaoyu Li, Dennis E. Vance
doaj   +1 more source