Results 11 to 20 of about 5,901 (191)

PEMT, Δ6 desaturase, and palmitoyldocosahexaenoyl phosphatidylcholine are increased in rats during pregnancy[S] [PDF]

Journal of Lipid Research, 2018
DHA is important for fetal neurodevelopment. During pregnancy, maternal plasma DHA increases, but the mechanism is not fully understood. Using rats fed a fixed-formula diet (DHA as 0.07% total energy), plasma and liver were collected for fatty acid ...
Alan Chalil, Alex P. Kitson, Juan J. Aristizabal Henao, Kristin A. Marks, Jason L. Elzinga, Daniel M.E. Lamontagne-Kam, Daniel Chalil, Flavia Badoud, David M. Mutch, Ken D. Stark   +9 more
doaj   +3 more sources

Patient-Derived Cancer-Associated Fibroblasts Support the Colonization of Tumor Cells in Head and Neck Squamous Cell Carcinoma [PDF]

Biomedicines
Background: The crosstalk between cancer-associated fibroblasts (CAFs) and tumor cells promotes proliferation, tumor relapse, and the acquisition of a partial epithelial-to-mesenchymal (pEMT) phenotype in tumor cells.
Julia Federspiel, Teresa Bernadette Steinbichler, Samuel Moritz Vorbach, Marie Theres Eling, Wegene Borena, Christof Seifarth, Benedikt Gabriel Hofauer, Jozsef Dudas   +7 more
doaj   +2 more sources

Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]

FASEB J
Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S.   +6 more
europepmc   +2 more sources

TTNPB Promotes Human Pluripotent Stem Cell-to-Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S-(5'-adenosyl)-L-homocysteine/Choline Metabolic Network. [PDF]

Adv Sci (Weinh)
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Du R, Ren Y, Meng Q, Wei P, Zhu R, Bao J, Yang Y, Yan S, Yue C, Zhu X, Cao S, Hao C, Sun W, Song Y, Li X, Wu Z, Bao S, Chen Y.   +17 more
europepmc   +2 more sources

Photo-Empowered Macrophage-Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery. [PDF]

Adv Sci (Weinh)
This study develops a photo‐empowered macrophage‐based (PEM) drug delivery system that provides a novel and effective solution for restoring cellular motility to enhance drug delivery and overcome hypoxia‐induced multidrug resistance. The construction of the PEM system fully exploits the unique biological properties of macrophages and the energy ...
Fu Z, Cui X, Liu S, Gao L, Sun Y, Chen Y, Li M, Fan Y, Kuang J, Song W, Zhou F.   +10 more
europepmc   +2 more sources

PEMT: a patent enrichment tool for drug discovery

Bioinformatics, 2022
Abstract Motivation Drug discovery practitioners in industry and academia use semantic tools to extract information from online scientific literature to generate new insights into targets, therapeutics and diseases. However, due to complexities in access and analysis, patent-based literature is
Yojana Gadiya, Andrea Zaliani, Philip Gribbon, Martin Hofmann-Apitius   +3 more
openaire   +2 more sources

Interplay between tumor microenvironment and partial EMT as the driver of tumor progression

iScience, 2021
Summary: Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has been extensively studied to address the unresolved variable treatment response across therapeutic regimes in cancer subtypes.
Vaishali Aggarwal, Catalina Ardila Montoya, Vera S. Donnenberg, Shilpa Sant   +3 more
doaj   +1 more source

The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes. [PDF]

Aging Cell
This study found that 3xTg‐AD mice exhibited lifelong reductions in circulating choline. Female 3xTg‐AD mice showed greater AD‐like pathology, whereas males displayed higher mortality, impulsivity, and water‐seeking behavior. These sex‐specific differences suggest distinct metabolic and behavioral vulnerabilities contributing to AD progression in this ...
Judd JM, Mistry F, Winslow W, Tallino S, Turk J, Velazquez R.   +5 more
europepmc   +2 more sources

Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

Biomolecules, 2022
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosynthesis of PC,
Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujić, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl   +11 more
doaj   +1 more source

Pharmacist involved education program in a multidisciplinary team for oral mucositis: Its impact in head-and-neck cancer patients.

PLoS ONE, 2021
ObjectivesThis retrospective study examined how a pharmacist-involved education program in a multidisciplinary team (PEMT) for oral mucositis (OM) affected head-and-neck cancer (HNC) patients receiving concurrent chemoradiotherapy (CCRT).Materials and ...
Kensuke Yoshida, Yasumitsu Kodama, Yusuke Tanaka, Kyongsun Pak, Marie Soga, Akira Toyama, Kouji Katsura, Ritsuo Takagi   +7 more
doaj   +1 more source