Results 21 to 30 of about 5,901 (191)

Hepatic Expression of PEMT, but Not Dietary Choline Supplementation, Reverses the Protection against Atherosclerosis in Pemt/Ldlr Mice [PDF]

The Journal of Nutrition, 2018
Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/-/low density lipoprotein receptor (Ldlr)-/- mice have significantly reduced plasma lipids and are protected against atherosclerosis. Recent studies have shown that choline can be metabolized by the gut flora into trimethylamine-N-oxide ...
Yumna, Zia, Ala, Al Rajabi, Si, Mi, Tingting, Ju, Kelly-Ann, Leonard, Randal, Nelson, Aducio, Thiesen, Benjamin P, Willing, Catherine J, Field, Jonathan M, Curtis, Jelske N, van der Veen, René L, Jacobs   +11 more
openaire   +2 more sources

Exploring undergraduate students’ experiences in dealing with post-editing of machine translation

Indonesian Journal of Applied Linguistics, 2022
Although post-editing of machine translation (PEMT) has been much discussed and spoken among students in higher education institutions, little empirical evidence has been reported regarding the students’ real practices in their academic life.
Sri Harto, Fuad Abdul Hamied, Bachrudin Musthafa, Sri Setyarini   +3 more
doaj   +1 more source

SLUG‐related partial epithelial‐to‐mesenchymal transition is a transcriptomic prognosticator of head and neck cancer survival

Molecular Oncology, 2022
Partial epithelial‐to‐mesenchymal transition (pEMT) contributes to cellular heterogeneity that is associated with nodal metastases and unfavorable clinical parameters in head and neck squamous cell carcinomas (HNSCCs).
Henrik Schinke, Min Pan, Merve Akyol, Jiefu Zhou, Enxian Shi, Gisela Kranz, Darko Libl, Tanja Quadt, Florian Simon, Martin Canis, Philipp Baumeister, Olivier Gires   +11 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinase Inhibition of Mesenchymal Transdifferentiated Tumor Cells in Head and Neck Squamous Cell Carcinoma

Biomedicines, 2023
High mortality in head and neck squamous cell carcinoma (HNSCC) is due to recurrence, metastasis, and radiochemotherapy (RCT) resistance. These phenomena are related to the tumor cell subpopulation undergoing partial epithelial to mesenchymal transition (
Julia Federspiel, Maria do Carmo Greier, Andrea Ladányi, Jozsef Dudas   +3 more
doaj   +1 more source

Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High-Fat Diet. [PDF]

FASEB Bioadv
Folic acid supplementation to high‐fat diets reduced hepatic steatosis in male C57BL/6J mice, as evidenced by lower triacylglycerol (TAG) levels in the liver. These effects were associated with increased hepatic choline availability, upregulation of choline‐metabolizing genes, and alterations in the hepatic fatty acid profile, suggestive of suppressed ...
Kranenburg E, Kubant R, Yang Z, Metherel AH, Chen CT, Beaudry JL, Cho CE, Vaz P, Anderson GH.   +8 more
europepmc   +2 more sources

Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. [PDF]

PLoS ONE, 2013
Recent studies have identified links between phospholipid composition and altered cellular functions in animal models of obesity, but the involvement of phospholipid biosynthesis genes in human obesity are not well understood.
Neeraj K Sharma, Kurt A Langberg, Ashis K Mondal, Swapan K Das   +3 more
doaj   +1 more source

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer [PDF]

, 2014
The current view of cancer progression highlights that cancer cells must undergo through a post-translational regulation and metabolic reprogramming to progress in an unfriendly environment.
Aspichueta, Patricia, Barbier Torres, Lucía, Beraza, Naiara, Boix, Loreto, Bruix, Jordi, Buqué, Xabier, Cano, Ainara, Castro, Azucena, Delgado, Teresa C, Fernández Domínguez, Itziar, Fernández Ramos, David, Fernández Tussy, Pablo, García Rodríguez, Juan L, Gutiérrez de Juan, Virginia, Lopitz Otsoa, Fernando, Lu, Shelly C, Martínez Chantar, María L., Mato, José M, Varela Rey, Marta, VILLA, Erica, Xirodimas, Dimitris, Zubiete Franco, Imanol   +21 more
core   +5 more sources

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Berg, Bestor, Bestor, Bestor, Boshart, Bradford, Cedar, de Villiers, Gluzman, Hergersberg, Kingston, Klempnauer, Matthias, Mellon, Morgenstern, Müller, Pfeifer, Pfeifer, Pósfai, Severne   +19 more
core   +1 more source

Insufficient glucose supply is linked to hypothermia upon cold exposure in high-fat diet-fed mice lacking PEMT[S]

Journal of Lipid Research, 2015
Mice that lack phosphatidylethanolamine N-methyltransferase (Pemt−/− mice) are protected from high-fat (HF) diet-induced obesity. HF-fed Pemt−/− mice show higher oxygen consumption and heat production, indicating that more energy might be utilized for ...
Xia Gao, Jelske N. van der Veen, Carlos Fernandez-Patron, Jean E. Vance, Dennis E. Vance, René L. Jacobs   +5 more
doaj   +1 more source

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Journal of Lipid Research, 2017
Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which is mainly ...
Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E. Vance, René L. Jacobs   +6 more
doaj   +1 more source