Results 31 to 40 of about 5,901 (191)

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

open access: yes, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna   +6 more
core   +2 more sources

Topological cell clustering in the ATLAS calorimeters and its performance in LHC Run 1 [PDF]

open access: yes, 2016
The reconstruction of the signal from hadrons and jets emerging from the proton–proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell
A Rimoldi   +2890 more
core   +27 more sources

Insights into the requirement of phosphatidylcholine synthesis for liver function in mice

open access: yesJournal of Lipid Research, 2003
Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC.
Anna A. Noga, Dennis E. Vance
doaj   +1 more source

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

open access: yesJournal of Lipid Research, 2007
The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.
Henkjan J. Verkade   +7 more
doaj   +1 more source

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD) [PDF]

open access: yesThe FASEB Journal, 2005
ABSTRACT Phosphatidylethanolamine N ‐methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in humans, nonalcoholic fatty liver disease (NAFLD) might be associated with PEMT
Jiannan, Song   +6 more
openaire   +2 more sources

Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice

open access: yesFrontiers in Immunology, 2020
FcgRIIB dysfunction is commonly found in patients with lupus, especially in Asia. LPS-tolerance is prominent in FcgRIIB–/– lupus mice. LPS-tolerant macrophages demonstrate cell energy depletion, which might affect lipid metabolism.
Thiranut Jaroonwitchawan   +6 more
doaj   +1 more source

Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma

open access: yesFrontiers in Immunology, 2022
BackgroundColon adenocarcinoma (COAD) is a common digestive system malignancy with high mortality and poor prognosis. Accumulating evidence indicates that choline metabolism is closely related to tumorigenesis and development.
Cong Liu   +27 more
doaj   +1 more source

Phosphatidylethanolamine N‐methyltransferase (PEMT) gene polymorphisms and risk of spina bifida [PDF]

open access: yesAmerican Journal of Medical Genetics Part A, 2006
Recently, our group demonstrated a reduction in risk of neural tube defects (NTDs) in infants of mothers who had elevated intakes of dietary choline [Shaw et al., 2004]. We hypothesized that disturbance in choline metabolism that are secondary to either a choline deficiency, or choline pathway genes mutations, may represent risk factors for NTDs ...
Jing, Zhang   +5 more
openaire   +2 more sources

Rhein Improves Renal Fibrosis by Restoring Cpt1a-Mediated Fatty Acid Oxidation through SirT1/STAT3/twist1 Pathway

open access: yesMolecules, 2022
The latest progress in the field of renal fibrosis mainly focuses on the new concept of “partial epithelial-mesenchymal transition (pEMT)” to explain the contribution of renal tubular epithelial (RTE) cells to renal fibrosis and the crucial role of fatty
Xianrui Song   +4 more
doaj   +1 more source

Eye-tracking as a measure of cognitive effort for post-editing of machine translation [PDF]

open access: yes, 2018
The three measurements for post-editing effort as proposed by Krings (2001) have been adopted by many researchers in subsequent studies and publications.
ALPAC   +37 more
core   +1 more source

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