Results 11 to 20 of about 31,010 (310)

Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice

Biomedicines, 2022
Traumatic brain injury (TBI) is often complicated by long-lasting disabilities, including headache, fatigue, insomnia, hyperactivity, and cognitive deficits.
Lisa Hahnefeld, Alexandra Vogel, Robert Gurke, Gerd Geisslinger, Michael K. E. Schäfer, Irmgard Tegeder   +5 more
doaj   +1 more source

Phosphatidylethanolamines Are Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Adults and Induce Liver Cell Metabolic Perturbations and Hepatic Stellate Cell Activation

International Journal of Molecular Sciences, 2023
Pathogenesis roles of phospholipids (PLs) in nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This study investigated the role of PLs in the progression of NAFLD among obese individuals via studying the alterations in serum PL ...
Samaa Shama, H. Jang, Xiaokun Wang, Yang Zhang, Nancy Nabil Shahin, T. Motawi, Seongho Kim, S. Gawrieh, Wanqing Liu   +8 more
semanticscholar   +1 more source

Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach

BMC Medicine, 2023
Background Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking.
Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui, Cuilin Zhang   +9 more
doaj   +1 more source

Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates

Scientific Reports, 2021
Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters.
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Vélez-Vega, Akram N. Alshawabkeh, José F. Cordero, John D. Meeker   +8 more
doaj   +1 more source

ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer [PDF]

Nature Communications, 2012
ATP-binding cassette (ABC) transporters comprise a superfamily of proteins, which actively transport a variety of compounds across cell membranes. Mammalian and most eukaryotic ABC transporters function as exporters, flipping or extruding substrates from the cytoplasmic to the extracellular or lumen side of cell membranes.
Robert S. Molday, Stepan Lenevich, Faraz Quazi   +2 more
openaire   +3 more sources

Spatial distribution of glycerophospholipids in the ocular lens. [PDF]

PLoS ONE, 2011
Knowledge of the spatial distribution of lipids in the intraocular lens is important for understanding the physiology and biochemistry of this unique tissue and for gaining a better insight into the mechanisms underlying diseases of the lens.
Jaroslav Pól, Veronika Vidová, Tuulia Hyötyläinen, Michael Volný, Petr Novák, Martin Strohalm, Risto Kostiainen, Vladimír Havlíček, Susanne K Wiedmer, Juha M Holopainen   +9 more
doaj   +1 more source

Increased ω6-Containing Phospholipids and Primary ω6 Oxidation Products in the Brain Tissue of Rats on an ω3-Deficient Diet. [PDF]

PLoS ONE, 2016
Polyunsaturated fatty acyl (PUFA) chains in both the ω3 and ω6 series are essential for normal animal brain development, and cannot be interconverted to compensate for a dietary deficiency of one or the other.
Paul H Axelsen, Robert C Murphy, Miki Igarashi, Stanley I Rapoport   +3 more
doaj   +1 more source

Untargeted UHPLC-TOF/MS Lipidomic Analysis for the Investigation of Egg Yolks after Xylanase Supplementation of the Diet of Laying Hens

Metabolites, 2023
Xylanase supplementation of diets is used to enhance nutrient digestibility in monogastrics which lack necessary enzymes for non-starch polysaccharide degradation.
Artemis Lioupi, Georgios A. Papadopoulos, Domniki Gallou, Christina Virgiliou, Georgios I. Arsenos, Paschalis Fortomaris, Veerle Van Hoeck, Dany Morisset, Georgios Theodoridis   +8 more
doaj   +1 more source

Phosphatidylethanolamine positively regulates autophagy and longevity [PDF]

Cell Death & Differentiation, 2015
Autophagy is a cellular recycling program that retards ageing by efficiently eliminating damaged and potentially harmful organelles and intracellular protein aggregates. Here, we show that the abundance of phosphatidylethanolamine (PE) positively regulates autophagy.
Rockenfeller, P., Koska, M., Pietrocola, F., Minois, N., Knittelfelder, O., Sica, V., Franz, J., Carmona-Gutierrez, D., Kroemer, G., Madeo, F.   +9 more
openaire   +6 more sources

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Journal of Clinical Investigation, 2018
Ferroptosis is a death program executed via selective oxidation of arachidonic acid–phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/
H. Dar, Y. Tyurina, K. Mikulska-Ruminska, I. Shrivastava, Hsiu-Chi Ting, V. Tyurin, James M. Krieger, C. S. St Croix, Simon C Watkins, Erkan Bayır, G. Mao, C. Armbruster, A. Kapralov, Hong Wang, M. Parsek, T. Anthonymuthu, Abiola F. Ogunsola, Becca A Flitter, Cody J. Freedman, J. Gaston, T. Holman, J. Pilewski, J. Greenberger, R. Mallampalli, Y. Doi, Janet S. Lee, I. Bahar, J. Bomberger, H. Bayır, V. Kagan   +29 more
semanticscholar   +1 more source