Results 71 to 80 of about 31,010 (310)

Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus

Scientific Reports, 2021
Diabetes mellitus (DM) is associated with a dysfunctional intestinal barrier and an increased risk for systemic infection and inflammation in people, though the pathogenic mechanisms leading to this are poorly understood.
Katti R. Crakes, Jully Pires, Nina Quach, Riley E. Ellis-Reis, Rachel Greathouse, Kathyrnne A. Chittum, Jörg M. Steiner, Patricia Pesavento, Stanley L. Marks, Satya Dandekar, Chen Gilor   +10 more
doaj   +1 more source

Non‐targeted metabolite profiling reveals biochemical diversity of three East Asian mosses

Bulletin of the Korean Chemical Society, EarlyView.
Mosses are known for their bioactive composition and adaptation to environmental stresses. This study explores the metabolic diversity of three East Asian moss species, Niphotrichum japonicum, Calohypnum plumiforme, and Polytrichum formosum, using high‐resolution mass spectrometry. Lipids, particularly unsaturated fatty acids linked to cold adaptation,
Fatima Tuz Zahra, Kyungwon Min, Jungeun Lee, Maeng‐Joon Jung, Hyoungseok Lee, Sunghwan Kim   +5 more
wiley   +1 more source

Trace elements and lipidomic datasets of stranding samples in the blubber of Turpsios truncatus from the Yucatan coast: Association with biological features

Data in Brief, 2023
The Yucatan coastal zone is an area that contributes to many anthropogenic activities resulting in substantial contamination (metals, pesticides) in aquatic organisms.
Ixchel M. Ruiz-Hernández, Mohammad-Zaman Nouri, Marianne Kozuch, Nancy D. Denslow, Raúl E. Díaz-Gamboa, Rossanna Rodríguez-Canul, Reyna C. Collí-Dulá   +6 more
doaj  

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017
Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown.
Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A. Kiebish, Laurie J. Goodyear, Kristin I. Stanford   +12 more
doaj   +1 more source

SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core

ChemBioChem, EarlyView.
The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic, Djenana Vejzovic, Altea Topciu, Kirill Kuhlmann, Raj Kumar, Maria Andrea Mroginski, Alejandra de Miguel, Pia Hofmann, Klaus Zangger, Markus Weingarth, Robert A. Cordfunke, Jan W. Drijfhout, Peter Nibbering, Michal Belicka, Karl Lohner, Nermina Malanovic   +15 more
wiley   +1 more source

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

Redox Biology, 2023
Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH), but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III clinical trial. Using a prolonged western diet-feeding murine NASH model,
Aoxiang Zhuge, Shengjie Li, Yin Yuan, Shengyi Han, Jiafeng Xia, Qiangqiang Wang, Shuting Wang, Pengcheng Lou, Bo Li, Lanjuan Li   +9 more
doaj  

Multi‐Omics Analysis Reveals the Selenium‐Regulatory Metabolism in Rare Yeast Kazachstania unispora KU2

Food Frontiers, EarlyView.
The mechanism of selenium‐regulatory unique metabolism in rare yeast Kazachstania unispora KU2 was explored via joint analysis of genomics, transcriptomics, and metabolomics. Arginine biosynthesis, glutathione metabolism, selenocompound metabolism, and TCA cycle were significantly associated with the selenium enrichment process in Kazachstania unispora
Furong Wang, Jiadi Zhang, Yilei Xiao, Zeyu Hu, Xian Wang, Yuqi Gao, Kewei Feng, Yahong Yuan, Tianli Yue   +8 more
wiley   +1 more source

Myelin Lipid Composition in the Central Nervous System Is Regionally Distinct and Requires Mechanistic Target of Rapamycin Signaling

Glia, EarlyView.
Brain oligodendrocytes have lower rates of cholesterol synthesis and higher rates of lipoprotein uptake than spinal cord oligodendrocytes. Myelin lipid content is higher in CNS regions with larger average axon diameter. Brain and spinal cord myelin cholesterol content is innately different, while myelin fatty acid content can be modulated by fiber ...
Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne, Wendy B. Macklin, Teresa L. Wood   +4 more
wiley   +1 more source