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Phosphatidylinositol synthase from yeast
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997PI is an important precursor for polyphosphoinositides and some sphingolipids and is also involved in the glycolipid anchoring of plasma membrane proteins. This lipid is synthesized from CDP-diacylglycerol and myo-inositol by PI synthase, an enzyme localized in the outer mitochondrial membranes and microsomes in yeast.
J, Nikawa, S, Yamashita
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Phosphatidylinositol synthesis in mycobacteria
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M +3 more
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Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase
Tetrahedron, 2000Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Naoko Morisaki +6 more
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Anti‐inflammatory actions of phosphatidylinositol
European Journal of Immunology, 2011AbstractChronic inflammatory T‐cell‐mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T‐cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less‐toxic alternatives.
Dieren, Jolanda +12 more
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays
2013Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Yang Ju, Im +4 more
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Phosphatidylinositol-transfer protein and cellular phosphatidylinositol metabolism
Biochemical Society Transactions, 1987P A, Van Paridon +2 more
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Plant Phosphatidylinositol 3-Kinase
2009Phosphatidylinositol 3-kinase (PI3K) phosphorylates the D-3 position of phosphoinositides. In Arabidopsis, only one PI3K exists, which belongs to the class-III PI3K subfamily which makes phosphatidylinositol 3-phosphate (PtdIns3P). The single AtPI3K gene is essential for survival, since loss of its expression results in lethality.
Lee, Y., Munnik, T., Lee, Y.
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Review of Phosphatidylinositol Phosphate Kinase in Phosphatidylinositol Signaling Pathway
2014Phosphatidylinositol signaling pathway is an important signal transduction pathway that plays critical roles in multiple cell processes first demonstrated in animal cells. Research evidences have shown that although not exactly the same as it is in yeast and mammalian cells, phosphatidylinositol signaling pathway also exists in plant cells and is ...
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