Results 311 to 320 of about 391,487 (338)

Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Cancer Letters, 2012
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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Phosphatidylinositol phosphate kinases.

Journal of endocrinological investigation, 2004
Phosphatidylinositol 4,5-bisphosphate is a multi-functional lipid, whose proposed functions now number more than twenty, covering many aspects of cell biology in several different subcellular compartments. The enzymes primarily responsible for synthesizing this lipid, the Type I phosphatidylinositol 4-phosphate 5-kinases, are therefore a tightly ...
Giudici, ML, Hinchliffe, KA, Irvine, RF
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Oncogenes and Phosphatidylinositol Turnover

Annals of the New York Academy of Sciences, 1986
Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses affect the steady-state level of ...
L C, Cantley, M, Whitman, S, Chahwala, L, Fleischman, D R, Kaplan, B S, Schaffhausen, T M, Roberts   +6 more
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Phosphatidylinositol synthase from yeast

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
PI is an important precursor for polyphosphoinositides and some sphingolipids and is also involved in the glycolipid anchoring of plasma membrane proteins. This lipid is synthesized from CDP-diacylglycerol and myo-inositol by PI synthase, an enzyme localized in the outer mitochondrial membranes and microsomes in yeast.
J, Nikawa, S, Yamashita
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Phosphatidylinositol synthesis in mycobacteria

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M, Lonsdale JT, Besra GS, Brennan PJ   +3 more
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Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase

Tetrahedron, 2000
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Naoko Morisaki, Koji Morita, Asuka Nishikawa, Noriyuki Nakatsu, Yasuhisa Fukui, Yuichi Hashimoto, Ryuichi Shirai   +6 more
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Anti‐inflammatory actions of phosphatidylinositol

European Journal of Immunology, 2011
AbstractChronic inflammatory T‐cell‐mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T‐cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less‐toxic alternatives.
Dieren, Jolanda, Oosterhuis, Ytje, Raatgeep, Rolien, Kortleve, Dicky, Lambers, Margaretha, van der Woude, C.J., Kuipers, Ernst, Snoek, GT, Potman, R, Lambrecht, Bart, Hammad, H (Hamida), Samsom, Janneke, Nieuwenhuis, EES   +12 more
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays

2013
Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Yang Ju, Im, Irena, Brglez, Catherine, Dieck, Imara Y, Perera, Wendy F, Boss   +4 more
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Phosphatidylinositol-transfer protein and cellular phosphatidylinositol metabolism

Biochemical Society Transactions, 1987
P A, Van Paridon, P, Somerharju, K W, Wirtz   +2 more
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Plant Phosphatidylinositol 3-Kinase

2009
Phosphatidylinositol 3-kinase (PI3K) phosphorylates the D-3 position of phosphoinositides. In Arabidopsis, only one PI3K exists, which belongs to the class-III PI3K subfamily which makes phosphatidylinositol 3-phosphate (PtdIns3P). The single AtPI3K gene is essential for survival, since loss of its expression results in lethality.
Lee, Y., Munnik, T., Lee, Y.
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