Results 321 to 330 of about 363,126 (392)

The formation of inositol 1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. Evidence for direct phosphodiesteratic cleavage of phosphatidylinositol.

, 1985
J F Dixon, L E Hokin
openalex   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

The Mechanisms of Lithium Action: The Old and New Findings. [PDF]

Pharmaceuticals (Basel)
Sakrajda K, Rybakowski JK.
europepmc   +1 more source

Pomegranate Extracts as Dual Regulators of Angiogenesis: A Systematic Review of Preclinical Evidence in Cancer and Chronic Wound Healing

Molecular Nutrition &Food Research, EarlyView.
Pomegranate extracts contain polyphenols with: anti‐angiogenic properties inhibiting angiogenesis in Cancer resulting in decreased cancer growth; pro‐angiogenic properties promoting angiogenesis in chronic wound healing hence increasing the healing process ABSTRACT Angiogenesis plays a critical role in both tumor progression and wound healing.
Anna Eleonora Caprifico, Gianpiero Calabrese, Riccardo Tornese, Anna Montefusco, Rocco Placì, Teodoro Semeraro, Miriana Durante, Monica De Caroli, Marcello Salvatore Lenucci   +8 more
wiley   +1 more source

Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer. [PDF]

Lipids Health Dis
Chytła A, Rattay S, Akgül B, Sztacho M.   +3 more
europepmc   +1 more source

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, EarlyView.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source

Enhanced Anti-Cancer Potential: Investigating the Combined Effects with <i>Coriolus versicolor</i> Extract and Phosphatidylinositol 3-Kinase Inhibitor (LY294002) In Vitro. [PDF]

Int J Mol Sci
Jędrzejewski T, Sobocińska J, Maciejewski B, Slovakova M, Wrotek S.   +4 more
europepmc   +1 more source

ATP‐Dependent Thermo‐Ring Basis for the Heat Unfolding of the First Nucleotide‐Binding Domain Isolated From Human CFTR

Natural Sciences, EarlyView.
The most common cystic fibrosis‐causing F508del mutation is located in the first nucleotide‐binding domain (hNBD1) of the human cystic fibrosis transmembrane conductance regulator (hCFTR). The ATP‐dependent weakest noncovalent bridge in isolated hNBD1 is found between two specific bold residues in the biggest thermo‐ring (highlighted in red) at or near
Guangyu Wang
wiley   +1 more source

To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.

World J Gastrointest Oncol
Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y.   +10 more
europepmc   +1 more source

Three signalling pathways for iron overload in osteoporosis: a narrative review. [PDF]

J Orthop Surg Res
Zou L, Chen G, Rong Y, Tang C, Lv X, Fan Y.   +5 more
europepmc   +1 more source