Results 191 to 200 of about 97,335 (259)

Therapeutic Potential of Berberis vulgaris in Modulating Metabolic Syndrome Biomarkers: Mechanistic Insights and Functional Food Implications

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Barberry (Berberis vulgaris) has emerged as a promising functional food candidate for the management of metabolic syndrome due to its diverse bioactive constituents, particularly berberine. This review synthesizes current experimental and clinical evidence regarding its effects on glycemic control, lipid metabolism, blood pressure regulation ...
Fakhar Shahid, Ifrah Jabeen, Muhammad Inam‐ur‐Raheem, Amin Mousavi Khaneghah, Muhammad Abid, Rana Muhammad Aadil   +5 more
wiley   +1 more source

In Vitro Models of Sturge-Weber Syndrome: Strengths, Limitations, and Future Goals. [PDF]

Int J Mol Sci
Manney AB, Nemeth CL, Comi AM.
europepmc   +1 more source

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, Volume 159, Issue 1, Page 269-279, 1 July 2026.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source

Distinct impact of PI(4)P flux on PI(4,5)P₂ steady states and oscillations. [PDF]

Proc Natl Acad Sci U S A
Xǔ XJ, Tong CS, Wu M.
europepmc   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Exploring the mechanism of the Lianshi Jianpi formula in treating impaired glucose tolerance: a network pharmacology, molecular docking, and experimental validation study. [PDF]

J Tradit Chin Med
Mingqian J, Tong W, Bowei H, Chen Q, Yanbin L, Binhua YE.   +5 more
europepmc   +1 more source

Soybean Inositol Polyphosphate 5‐Phosphatase 8 Confers Salt Tolerance by Reducing Sodium Influx Through Inositol 1,4,5‐Trisphosphate Signalling

Plant, Cell &Environment, Volume 49, Issue 7, Page 4420-4434, July 2026.
ABSTRACT Evidence suggests that the metabolism of inositol and its derivatives may be involved in various biological processes including salt tolerance, but there has been limited understanding. Ectopic expression of Gs5PTase8, an inositol polyphosphate 5‐phosphatase cloned from wild soybean (Glycine soja), significantly enhanced salt tolerance in ...
Qi Jia, Yuan Chen, Defeng Kong, Hanyu Fan, Song Sun, Yuhang Liu, Jiahui Fu, Man‐Wah Li, Fuk‐Ling Wong, Qinghua Li, Kangjing Liang, Hon‐Ming Lam, Wen‐Xiong Lin   +12 more
wiley   +1 more source

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma Membrane. [PDF]

Int J Mol Sci
Ramos-Jiménez A, Rubio-Valles M, Guereca-Arvizuo J, Juárez-Oropeza MA, Ramos-Hernández JA, Chávez-Guevara IA, González-Rodríguez E, Moreno-Brito V, Hernández Torres RP.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB. [PDF]

Biochem J
Chu N, Le N, Nebie O, Yang S.
europepmc   +1 more source