Results 201 to 210 of about 97,335 (259)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA. [PDF]

Mol Med Rep
Zhan S, Wang C, Yin F.
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

The PI3K/AKT signaling networks in cancer glucose metabolism: mechanisms and therapeutic implications. [PDF]

Transl Oncol
Cheng S, Jiang Q, Huang H, Tong H, Xie M.   +4 more
europepmc   +1 more source

Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer‐like pathology

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
A graphical abstract is provided to visually summarize the key findings of this study. Abstract INTRODUCTION Periodontal pathogen Porphyromonas gingivalis is epidemiologically linked to Alzheimer's disease (AD), yet how oral infection disrupts the central circadian clock to drive hippocampal neurodegeneration remains unknown.
Chunmei Huang, Qin Cai, Zeru Feng, Chenze Zhang, Zhiqiang Luo, Xingqun Cheng, Hongkun Wu   +6 more
wiley   +1 more source

Recurrent Genomic Alterations in BCRi‐Experienced CLL Patients Treated With Venetoclax: Extended Phase 2 Follow‐Up

American Journal of Hematology, Volume 101, Issue 7, Page 1516-1521, July 2026.
Jennifer A. Woyach, Relja Popovic, Emily L. Rossi, Sanjana Singh, Toshihiko Oki, Tanya S. Rosenberg, Chen Qian, Michael Moran, Zihuan Liu, Michelle Boyer, Jeffrey Jones, Richard R. Furman, William Wierda, Jason Gotlib, Stephen J. Schuster, Brenda Chyla, Matthew S. Davids   +16 more
wiley   +1 more source

Comparative Phosphoproteomics of Two <i>Flammulina filiformis</i> Cultivars with Differential Postharvest Browning Susceptibility. [PDF]

J Fungi (Basel)
Fu Y, Guo X, He X, Wang B, Peng W, Yu Y.
europepmc   +1 more source

Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease. [PDF]

Circ Res
Westhoff M, Voelker TL, Del Villar SG, Thai PN, Voorhees HM, Roslan FF, Martin JL, Bossuyt J, Sirish P, Chiamvimonvat N, Nieves-Cintrón M, Dickson EJ, Dixon RE.   +12 more
europepmc   +1 more source

Treatment with Kinase Inhibitors Plus Myo-Inositol as Re-Differentiating Agents in Iodine-Refractory Thyroid Cancers. [PDF]

Life (Basel)
Giani C, Russo M, Lapi P, Profilo MA, Forleo R, Mazzi B, Ghirri A, Caresia L, Campennì A, Durante C, Corsello A, Morganti R, Unfer V, Paragliola RM, Barbaro D.   +14 more
europepmc   +1 more source

PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking. [PDF]

PLoS Genet
Reimann GR, Edeen PT, Conquest S, Grant BD, Fay DS.   +4 more
europepmc   +1 more source