Results 331 to 340 of about 405,250 (376)

Role of Oxysterol-Binding Protein Family in Cholesterol Metabolism and Cancer Progression: A Review. [PDF]

Med Sci Monit
Wu Y, Lv X, Yang J, Liu S, Chen Y, Yuan Z, Wang X.   +6 more
europepmc   +1 more source

[Expression of Concern] PI3K/Akt signaling pathway‑induced heme oxygenase‑1 upregulation mediates the adaptive cytoprotection of hydrogen peroxide preconditioning against oxidative injury in PC12 cells. [PDF]

Int J Mol Med
Mo L, Yang C, Gu M, Zheng D, Lin L, Wang X, Lan A, Hu F, Feng J.   +8 more
europepmc   +1 more source

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases. [PDF]

J Biol Chem
Hodapp SJ, Kao TH, Wu J, Balasuriya N, Antal CE, Taylor SS, Newton AC.   +6 more
europepmc   +1 more source

Effect of Jiawei Huangqi Guizhi decoction on the expression of gastrin content and phosphatidylinositol 3-kinase/ protein kinase B/mechanistic target of rapamycin complex 2 signalling pathways in rats with chronic atrophic gastritis.

Zhou Xia, Liang Kaiqing, Weigang Chen, Yong Cao, Duo Hongdong, L I Qiangbin, ANDY YUN   +6 more
openalex   +2 more sources

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Phosphatidylinositol 3-kinase related kinases

Current Opinion in Immunology, 1996
Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical ...
R. Abraham
openaire   +3 more sources

Phosphatidylinositol 3-Kinase Pathway

2014
The phosphatidylinositol 3-kinase (PI3K) pathway is one of the signalling pathways activated following the interaction of a growth factor with a tyrosine kinase receptor (TKR). It follows a parallel path to the MAP kinase pathway, and similarly, it operates after binding a phosphotyrosine residue of the receptor to an adapter protein.
J. Robert
openaire   +2 more sources

Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Journal of Medicinal Chemistry, 2014
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage.
Martin, Andrs, Jan, Korabecny, Daniel, Jun, Zdenek, Hodny, Jiri, Bartek, Kamil, Kuca   +5 more
openaire   +3 more sources

Phosphatidylinositol 3‐kinase

BioEssays, 1994
AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
R, Kapeller, L C, Cantley
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Plant Phosphatidylinositol 3-Kinase

2009
Phosphatidylinositol 3-kinase (PI3K) phosphorylates the D-3 position of phosphoinositides. In Arabidopsis, only one PI3K exists, which belongs to the class-III PI3K subfamily which makes phosphatidylinositol 3-phosphate (PtdIns3P). The single AtPI3K gene is essential for survival, since loss of its expression results in lethality.
Lee, Y., Munnik, T., Lee, Y.
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Phosphatidylinositol 3-Kinase in Myogenesis

Trends in Cardiovascular Medicine, 1997
Phosphatidylinositol 3-kinase (PI 3-kinase) has been cloned and characterized in a wide range of organisms. PI 3-kinases are activated by a diversity of extracellular stimuli and are involved in multiple cell processes such as cell proliferation, protein trafficking, cell motility, differentiation, regulation of cytoskeletal structure, and apoptosis ...
P, Kaliman, A, Zorzano
openaire   +2 more sources