A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. [PDF]
, 2019 Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the ...
Clanton, Joshua A +10 more
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Innate immunity shapes the persistent transmission of plant viruses by insect vectors
New Plant Protection, EarlyView.In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley +1 more source
Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion
Translational OncologyPhosphoinositide signaling pathway has garnered significant attention in recent years due to its implication in metabolic alterations associated with various human diseases, including breast cancer.
Yue Jin +3 more
doaj +1 more source
An Arabidopsis mutant deficient in phosphatidylinositol-4-phosphate kinases ß1 and ß2 displays altered auxin-related responses in roots. [PDF]
Sci Rep, 2022 Starodubtseva A +12 more
europepmc +1 more source
Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Portal Hypertension &Cirrhosis, EarlyView.MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang +5 more
wiley +1 more source
The involvement of oxysterol-binding protein related protein (ORP) 6 in the counter-transport of phosphatidylinositol-4-phosphate (PI4P) and phosphatidylserine (PS) in neurons. [PDF]
Biochem Biophys Rep, 2022 Mochizuki S, Miki H, Zhou R, Noda Y.
europepmc +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. [PDF]
J Biol Chem, 2022 Yan Q, Gao H, Yao Q, Ling K, Xiao G.
europepmc +1 more source
Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels
Journal of Biosciences, 2018 In Hedgehog (Hh) signalling, Hh ligand concentration gradient is effectively translated into a spatially distinct transcriptional program to give precisely controlled context dependent developmental outcomes. In the absence of Hh, the receptor Patched (Ptc) inhibits the signal transducer Smoothened (Smo) by maintaining low phosphatidylinositol 4 ...
openaire +2 more sources
Phytotherapy Research, EarlyView.EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun +7 more
wiley +1 more source