Results 121 to 130 of about 19,012 (341)

Time-Resolved Ultrastructural Detection of Phosphatidylinositol 3-Phosphate [PDF]

Journal of Histochemistry & Cytochemistry, 2010
Phosphatidylinositol 3-phosphate [Ptdlns(3)P] playsan important role in recruitment of various effector proteins in the endocytic and autophagic pathways. In an attempt to follow the distribution of Ptdlns(3)P at the ultrastructural level, we are using the Fab1, YOTB, Vac1, and EEA1 (FYVE) domain, which is a zinc finger motif specifically binding to ...
Susanne Stuffers, Lene Malerød, Silvia Corvera, Andreas Brech, Kay Oliver Schink, Harald Stenmark   +5 more
openaire   +2 more sources

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.

PLoS ONE, 2009
BackgroundThe fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Tania Maffucci, Claudio Raimondi, Shadi Abu-Hayyeh, Veronica Dominguez, Gianluca Sala, Ian Zachary, Marco Falasca   +6 more
doaj   +1 more source

Synthesis of deuterated phosphatidylinositol phosphates [PDF]

, 2016
Phosphatidylinositol phosphates (PtdInsPn) are intracellular signalling molecules that are important in many key biological processes, in particular Ca2+ signalling pathways.
Saunders, Alex
core   +1 more source

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

The voltage sensing phosphatase (VSP) localizes to the apical membrane of kidney tubule epithelial cells.

PLoS ONE, 2019
Voltage-sensing phosphatases (VSPs) are transmembrane proteins that couple changes in membrane potential to hydrolysis of inositol signaling lipids.
Wil Ratzan, Vamseedhar Rayaprolu, Scott E Killian, Roger Bradley, Susy C Kohout   +4 more
doaj   +1 more source

Metabolomics-coupled functional pharmacology of chlorophyll compounds isolated from the leaves of Ficus Exasperata Vahl (Moraceae) provides novel pathways on myometrial activity [PDF]

, 2017
New chlorophyll derivatives (pheophytins along with pheophorbide derivatives) were isolated from the leaves of Ficus exasperata and were found to have varying effects on uterine contractility.
Bafor, Enitome E., Edrada-Ebel, RuAngelie, Rowan, Edward G.   +2 more
core   +1 more source

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

Deciphering interplay between Salmonella invasion effectors [PDF]

, 2007
Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells.
AL Rozelle, BB Finlay, CE Stebbins, CM Collazo, D Vignjevic, D Zhou, D Zhou, EC Boyle, EJ McGhie, EJ McGhie, FA Norris, H Guillou, J Chang, J Chang, JB Morris, JC Patel, JC Patel, JE Galan, JE Galan, K Muramoto, K Niebuhr, K Ohnishi, LC Brawn, LD Hernandez, LD Hernandez, LM Chen, MC Schlumberger, MJ Garner, MR Terebiznik, P Cossart, P Dean, R Rohatgi, Ralph R. Isberg, RD Hayward, RD Hayward, RD Hayward, RD Hayward, Richard D. Hayward, RJ Cain, Robert J. Cain, S Andrews, S Stender, T Kubori, Vassilis Koronakis, WD Hardt, Y Fu   +45 more
core   +4 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source