Results 321 to 330 of about 19,012 (341)

Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Cancer Letters, 2012
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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Characterization of phosphatidylinositol and phosphatidylinositol-4-phosphate kinases in human neutrophils.

The Journal of Immunology, 1988
Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
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Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Lipids in search of a function

Cell Calcium, 1982
Recent years have seen a rapid accumulation of information which relates to the idea that receptor-controlled effects on inositol lipid metabolism might somehow be involved in the control of stimulated cells (see refs 1–14 for reviews). Most of these studies have been concerned only with phosphatidylinositol (PtdIns) and have tended to ignore the ...
Peter Downes, Robert H. Michell
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ChemInform Abstract: General Synthesis of Phosphatidylinositol 3‐Phosphates.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Robert J. Kubiak, Karol S. Bruzik
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The phosphatidylinositol 4-phosphate 5-kinase family

Advances in Enzyme Regulation, 1996
The existence of a PIP5K family of enzymes has been suggested by Western blotting and purification of numerous PIP5Ks from various tissues and cell types. The erythrocyte has at least two PIP5Ks, named PIP5KI and PIP5KII, while the brain appears to have even more isoforms.
Igor V. Boronenkov, Joost C. Loijens, Richard A. Anderson, Gregory J. Parker   +3 more
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Intracellular trafficking and turnover of phosphatidylinositol 3-phosphate

Seminars in Cell & Developmental Biology, 2001
Phosphatidylinositol 3-kinases (PI 3-kinases) regulate cellular functions through the 3'-phosphorylation of phosphatidylinositol (PI) and its derivatives. The PI 3-kinase product phosphatidylinositol 3-phosphate [PI(3)P] functions to recruit and activate effector proteins containing FYVE zinc finger domains.
David J. Gillooly, Harald Stenmark
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays

2013
Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Wendy F. Boss, Irena Brglez, Yang Ju Im, Imara Y. Perera, Catherine B. Dieck   +4 more
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Enzymatic synthesis and hydrolysis of [32P]phosphatidylinositol phosphate

Biochemical and Biophysical Research Communications, 1985
Phosphatidylinositol kinase activity in plasma membrane preparations of mouse liver was found to be comparable to that in A431 cells and higher than that in three human tumor xenografts. This activity was exploited in preparing 32P-labeled phosphatidylinositol phosphate of high specific radioactivity in which approximately 4% of the radioactivity of ...
C.Martin Lawrence, Aileen F. Knowles
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Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4‐phosphate 5‐kinase‐Iβ for phosphatidylinositol‐4‐phosphate

Journal of Cellular Biochemistry, 2006
AbstractType I phosphatidylinositol 4‐phosphate 5‐kinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the activation of PIP5K pathways in vivo.
J. Nathan Davis, Marta Jarquin-Pardo, Eric A. First, Abbie Fitzpatrick, Floyd J. Galiano   +4 more
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Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate

Biochemical and Biophysical Research Communications, 1985
Phosphatidylinositol 4,5-bisphosphate (PIP2) is enzymatically produced when high speed supernatant fraction from bovine retina is incubated with [gamma-32P]ATP and phosphatidylinositol 4-phosphate (PIP) as substrates. Exogenously added PIP2 inhibits PIP kinase activity 50% at equimolar concentrations of product and substrate.
Nicolas G. Bazan, Lucio A.A. Van Rooijen, Magdalena J. Rossowska   +2 more
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