Results 71 to 80 of about 19,012 (341)
Frontiers in Molecular Biosciences, 2023 Complex mechanisms regulate the cellular distribution of cholesterol, a critical component of eukaryote membranes involved in regulation of membrane protein functions directly and through the physiochemical properties of membranes.
Hengyi Xie +2 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Functional, pathogenic, and pharmacological roles of protein folding intermediates
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley +1 more source
Synaptojanin2 Mutation Causes Progressive High-frequency Hearing Loss in Mice
Frontiers in Cellular Neuroscience, 2020 Progressive hearing loss is very common in the human population but we know little about the underlying molecular mechanisms. Synaptojanin2 (Synj2) has been reported to be involved, as a mouse mutation led to a progressive increase in auditory thresholds
Elisa Martelletti +7 more
doaj +1 more source
A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-κB activation. [PDF]
PLoS ONE, 2014 Toll-like receptor signaling, mediated by functional Toll/interleukin-1 receptor (TIR) domains, plays a critical role in activating the innate immune response responsible for controlling and clearing infection.
Jun Zou +3 more
doaj +1 more source
The use of trade data in the analysis of global phosphate flows [PDF]
arXiv, 2023 In this paper we present a new method to trace the flows of phosphate from the countries where it is mined to the countries where it is used in agricultural production. We achieve this by combining data on phosphate rock mining with data on fertilizer use and data on international trade of phosphate-related products.
arxiv
Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]
, 2002 Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe +4 more
core +3 more sources
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Phosphatidylinositol phosphate kinases (PIPKs) generate two highly important phosphatidylinositol bisphosphates, PI(4,5)P 2 and PI(3,5)P 2 , which are central to many signaling and membrane trafficking processes.
Xiang Gao +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
PLoS Biology, 2022 Cell division, wherein 1 cell divides into 2 daughter cells, is fundamental to all living organisms. Cytokinesis, the final step in cell division, begins with the formation of an actomyosin contractile ring, positioned midway between the segregated ...
Govind Kunduri +11 more
doaj +1 more source