Results 311 to 320 of about 79,046 (379)

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Impact of subclinically hypocalcemic stress on the plasma metabolomic profile of dairy goats. [PDF]

Anim Biosci
Zhang J, Yang D, Zeng Y, Guo K, Zhang J, Huang Y, Sui Y, Liu Q, Mo X, Zhao C, Wang J.   +10 more
europepmc   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

The Role of Nuclear Phosphoinositides in the p53-MDM2 Nexus. [PDF]

Cells
Lee JH, Salah MK, Salah MK, Chen X, Kucherenko NV, Cryns VL, Anderson RA.   +6 more
europepmc   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease. [PDF]

J Proteome Res
Ferreira HB, van Merrienboer T, Guerra IMS, Melo T, Yeung KK, Ayyalasomayajula V, Trindade F, Nogueira-Ferreira R, Leite-Moreira A, Goracci L, Ferreira R, Domingues MR, Dias-Neto M, VASCUL-AID Consortium.   +13 more
europepmc   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

Untargeted lipidomics reveals racial differences in lipid species among women. [PDF]

Biomark Res
Pourali G, Li L, Getz KR, Jeon MS, Luo J, Luo C, Toriola AT.   +6 more
europepmc   +1 more source

Phosphatidylinositol 3,5-bisphosphate: A Molecular Switch of Vacuolar Fusion and Fission

, 2018
Annie Guo, Gregory E. Miner, Katie Sullivan   +2 more
openalex   +1 more source

Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein

The FEBS Journal, EarlyView.
An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj, Tadeja Bele, Anastasija Panevska, Gregor Bajc, Jan Kejžar, Miha Bahun, Nataša Poklar Ulrih, Valentina Levak, Matej Skočaj, Larisa Lara Popošek, Peter Veranič, Nataša Resnik, Kristina Sepčić   +12 more
wiley   +1 more source