Results 111 to 120 of about 133,958 (282)

The small molecule CBR-5884 inhibits theCandida albicansphosphatidylserine synthase [PDF]

, 2023
Yue Zhou, Gregory A. Phelps, Mikayla M. Mangrum, Jemma McLeish, Elise K. Phillips, Jinchao Lou, Christelle F. Ancajas, Jeffrey M. Rybak, Peter Oelkers, Richard Lee, Michael D. Best, Todd B. Reynolds   +11 more
openalex   +1 more source

Membrane Binding and Bending in Ebola VP40 Assembly and Egress

Frontiers in Microbiology, 2014
Lipid-enveloped viruses contain a lipid bilayer coat that protects their genome and helps to facilitate entry into the host cell. Filoviruses are lipid-enveloped viruses that have up to 90% clinical fatality and include Marbug (MARV) and Ebola (EBOV ...
Robert V Stahelin, Robert V Stahelin
doaj   +1 more source

Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles

Cells, 2020
Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevated phosphatidylserine (PS) on their membrane surface compared to healthy cells.
Harold W. Davis, Subrahmanya D. Vallabhapurapu, Zhengtao Chu, Michael A. Wyder, Kenneth D. Greis, Venette Fannin, Ying Sun, Pankaj B. Desai, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi   +10 more
doaj   +1 more source

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

Nature Communications, 2018
Myotube formation by fusion of myoblasts and subsequent elongation of the syncytia is essential for skeletal muscle formation. However, molecules that regulate myotube formation remain elusive. Here we identify PIEZO1, a mechanosensitive Ca2+ channel, as
Masaki Tsuchiya, Y. Hara, Masakiyo Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, K. Nagao, Masayuki X. Mori, Y. Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka, T. Ohwada, J. Aoki, M. Kanagawa, T. Toda, Y. Nagata, R. Matsuda, Yasunori Takayama, M. Tominaga, M. Umeda   +20 more
semanticscholar   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles [PDF]

, 2013
We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF.
Collier, Mary E. W., Ettelaie, Camille, Maraveyas, Anthony   +2 more
core   +1 more source

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7nr06966a

Nanoscale, 2018
Decoration of isolated extracellular vesicles with recombinant phosphatidylserine-binding nanobodies increases their uptake by tumor cells.
S. Kooijmans, Jerney J. Gitz-Francois, R. Schiffelers, P. Vader   +3 more
semanticscholar   +1 more source

Triggering of Programmed Erythrocyte Death by Alantolactone

Toxins, 2014
The sesquiterpene alantolactone counteracts malignancy, an effect at least in part due to stimulation of suicidal death or apoptosis of tumor cells.
Kousi Alzoubi, Salvatrice Calabrò, Jasmin Egler, Caterina Faggio, Florian Lang   +4 more
doaj   +1 more source

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization

Nature Communications, 2019
Fertilization is essential for species survival. Although Izumo1 and Juno are critical for initial interaction between gametes, additional molecules necessary for sperm:egg fusion on both the sperm and the oocyte remain to be defined.
C. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, S. Arandjelovic, Chang Sup Lee, K. Wheeler, Ryan P. Smith, L. Haney, B. Isakson, S. Purcell, J. Lysiak, K. Ravichandran   +12 more
semanticscholar   +1 more source

Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells [PDF]

, 2021
Alana MacDonald, Brandon Lam, John Lin, Louise Ferrall, Yu Jui Kung, Ya Chea Tsai, T.‐C. Wu, Chien‐Fu Hung   +7 more
openalex   +1 more source