Results 101 to 110 of about 73,519 (304)

Induction of Suicidal Erythrocyte Death by Cantharidin

Toxins, 2015
The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells,
Kousi Alzoubi, Jasmin Egler, Marilena Briglia, Antonella Fazio, Caterina Faggio, Florian Lang   +5 more
doaj   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Control of Endocytic Trafficking and Recycling Pathways by Phosphatidylserine in S. cerevisiae  [PDF]

MSc thesis investigating the roles of Phosphatidylserine in endocytic trafficking and mechanisms of Phosphatidylserine distribution in yeast.Phosphatidylserine (PS) is the most abundant anionic phospholipid in cells.
Sapp, David Graham
core  

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Characterization of Phosphatidylserine Expression in Bovine Sperm [PDF]

, 2021
Many factors influence male fertility, and conventional fertility evaluations are not able to reliably identify sub-fertile animals. The overall goal of this work was to explore the expression of phosphatidylserine (PS) on bovine sperm and investigate ...
Haines, Hannah
core  

Aminoglycoside induces RIPOR2 translocation and phosphatidylserine externalization via distinct mechanisms

Frontiers in Cellular Neuroscience
Aminoglycosides are widely used to treat severe infections. However, systemically administered AGs preferentially kill cochlear hair cells, resulting in irreversible hearing loss. Recently, we found that AGs induce a rapid translocation of RIPOR2 in hair
Jinan Li, Michelle Yang, Bo Zhao, Bo Zhao, Bo Zhao   +4 more
doaj   +1 more source

Altered brain lipid composition in cyclooxygenase-2 knockout mouse

Journal of Lipid Research, 2007
Cyclooxygenase (COX)-2 plays an important role in brain arachidonic acid (20:4n-6) metabolism, and its expression is upregulated in animal models of neuroinflammation and excitotoxicity. Our hypothesis was that brain lipid composition would be altered in
Kaizong Ma, Robert Langenbach, Stanley I. Rapoport, Mireille Basselin   +3 more
doaj   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

On the mechanism of the mitochondrial decarboxylation of phosphatidylserine [PDF]

To study intramitochondrial phospholipid flow, radiolabeled phosphatidylserine was introduced into isolated rat liver mitochondria from donor vesicles through the action of a nonspecific lipid transfer protein.
de Kruijff, B., Hovius, R., Brigot, B., Faber, B., Nicolay, K.   +4 more
core   +1 more source

Phosphatidylserine exposure by apoptotic cells:a phylogenetically conserved mechanism [PDF]

, 1998
Tolerance of the existence of the individual cell in multicellular organisms is mediated by the distribution of the various phospholipid species across the bilayer of the plasma membrane.
Baehrecke, Eric H., Vermeij-Keers, Christl, Reutelingsperger, Chris P.M., Boshart, Lenard, van den Eijnde, Stefan M.   +4 more
core   +4 more sources