Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Erythrocytes possess an unusual programmed cell death mechanism termed eryptosis, and several compounds have been previously claimed to induce eryptosis in vitro.
TERESA G Carvalho +2 more
exaly +7 more sources
Eryptosis as a New Insight in Malaria Pathogenesis [PDF]
Frontiers in Immunology, 2022 Eryptosis is a programmed cell death-like process that occurs in red blood cells. Although the red blood cells are anucleated, there are similarities between eryptosis and apoptosis, such as increased calcium efflux, calpain activation ...
Totino Paulo Renato Rivas +1 more
exaly +6 more sources
Eryptosis in Liver Diseases: Contribution to Anemia and Hypercoagulation [PDF]
Medical SciencesEryptosis is a type of regulated cell death of mature erythrocytes characterized by excessive Ca2+ accumulation followed by phosphatidylserine externalization.
Saulesh Kurmangaliyeva +7 more
doaj +4 more sources
Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations [PDF]
Cell Death and DiseaseEarly studies have shown that erythrocytes have caspase-3 and caspase-8 and are capable of dying through an apoptotic-like cell death triggered by Ca2+ ionophores.
Anton Tkachenko +17 more
doaj +4 more sources
Eryptosis in renal anemia: mechanisms, clinical implications, and therapeutic targeting [PDF]
Frontiers in PharmacologyRenal anemia is one of the most common complications of chronic kidney disease (CKD) and is associated with serious clinical consequences. Its prevalence increases significantly as renal function declines, affecting over 90% of dialysis patients ...
Xiang Deng +9 more
doaj +5 more sources
Red Cell Death in Renal Disease: The Role of Eryptosis in CKD and Dialysis Patients [PDF]
CellsEryptosis is a programmed cellular death involving red blood cells (RBCs). It is a physiological mechanism that leads to the removal of defective erythrocytes, similarly to apoptosis.
Grazia Maria Virzì +3 more
doaj +4 more sources
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes [PDF]
Frontiers in Cell and Developmental Biology, 2020 Erythrocytes are among the most abundant cells in mammals and are perfectly adapted to their main functions, i.e., the transport of O2 to peripheral tissues and the contribution to CO2 transport to the lungs.
Michael Foller +2 more
exaly +5 more sources
Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia [PDF]
Frontiers in Immunology, 2020 Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO) bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO are known to modulate eryptosis in healthy red blood cells (RBCs); however, their role
Philippe Joly +2 more
exaly +4 more sources
Geraniol Exerts Cytotoxic Effects in Red Cells Through Ca2+ Elevation and Membrane Hyperpolarization: Attenuating Effects of COX/CK1α/Rac1 GTPase Inhibition [PDF]
MoleculesBackground: Hemolysis and eryptosis of red blood cells (RBCs) contribute to chemotherapy-induced anemia, a marker of poor prognosis. Geraniol (GER) is an anticancer acyclic monoterpene alcohol found in several plant extracts, but a dearth of evidence ...
Mohammad A. Alfhili +2 more
doaj +2 more sources
Eryptosis in Acute Patients: A Hypothesis on Its Potential Clinical Impact and Current Gaps in Evidence [PDF]
Current Issues in Molecular BiologySepsis is a life-threatening condition driven by a dysregulated host response to infection and remains a leading cause of mortality and morbidity worldwide.
Grazia Maria Virzì +3 more
doaj +2 more sources