Results 41 to 50 of about 2,020 (175)

What should be responsible for eryptosis in chronic kidney disease?

Kidney & Blood Pressure Research, 2022
Background: Renal anemia is an important complication of chronic kidney disease (CKD). In addition to insufficient secretion of erythropoietin (EPO) and erythropoiesis disorders, the impact of eryptosis on renal anemia demands attention.
Dongxin Li, Xujuan Zheng, Yunxia Zhang, Xiangling Li, Xuexun Chen, Yonghua Yin, Jingwen Hu, Jialin Li, Min Guo, Xiangming Wang   +9 more
doaj   +1 more source

Enhanced Eryptosis Following Exposure to Dolutegravir [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: The viral integrase enzyme inhibitor dolutegravir is utilized for the treatment of immunodeficiency virus (HIV) infection. Knowledge on cytotoxicity of dolutegravir is limited. The present study thus explored, whether dolutegravir is able to trigger suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and ...
A. A. M. Bhuyan, E. Signoretto, R. Bissinger, F. Lang   +3 more
openaire   +4 more sources

Studying Mechanisms of Eryptosis [PDF]

Cytotechnology, 2005
Cellular stress leads to activation of erythrocyte cation channels with subsequent Ca2+ entry and stimulates a sphingomyelinase with subsequent formation of ceramide. Both signaling molecules then activate the death program of erythrocytes (eryptosis) which is characterized by phosphatidylserine exposure, cellular shrinkage, membrane blebbing and ...
Thomas Wieder, Philipp A. Lang, Karl S. Lang, Daniela S. Kempe, Olivier M. Niemoeller, Christophe Duranton, Erich Gulbins, Stephan M. Huber, Florian Lang   +8 more
openaire   +1 more source

Atorvastatin Induced Erythrocytes Membrane Blebbing

Dose-Response, 2019
Atorvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzymeA reductase, is usually used for the treatment of hypercholesterolemia. Besides its pharmacological and side actions, its toxic effects on human nucleus devoid of erythrocytes are still ...
Rumaisa Bashir Rana, Kashif Jilani, Muhammad Shahid, Muhammad Riaz, Mazhar Hussain Ranjha, Ismat Bibi, Asma Asghar, Muhammad Irfan   +7 more
doaj   +1 more source

The Role of Eryptosis in the Pathogenesis of Renal Anemia: Insights From Basic Research and Mathematical Modeling

Frontiers in Cell and Developmental Biology, 2020
Red blood cells (RBC) are the most abundant cells in the blood. Despite powerful defense systems against chemical and mechanical stressors, their life span is limited to about 120 days in healthy humans and further shortened in patients with kidney ...
Gabriela Ferreira Dias, Gabriela Ferreira Dias, Nadja Grobe, Sabrina Rogg, David J. Jörg, Roberto Pecoits-Filho, Roberto Pecoits-Filho, Andréa Novais Moreno-Amaral, Peter Kotanko, Peter Kotanko   +9 more
doaj   +1 more source

Stimulation of Eryptosis by Anti-A IgG Antibodies [PDF]

Cellular Physiology and Biochemistry, 2007
Anti-A IgG antibodies have previously been shown to stimulate Ca(2+) entry into red blood cells. Increased cytosolic free Ca(2+) concentration is known to trigger eryptosis, i.e. suicidal erythrocyte death, characterized by exposure of phosphatidylserine at the erythrocyte surface.
Philipp, Attanasio, Ekaterina, Shumilina, Tobias, Hermle, Valentin, Kiedaisch, Philipp A, Lang, Stephan M, Huber, Thomas, Wieder, Florian, Lang   +7 more
openaire   +2 more sources

Eryptosis as a marker of Parkinson's disease

Aging, 2014
A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases.
Pretorius, Etheresia, Swanepoel, A.C. (Albe Carina), Buys, A.V. (Antonia Vergina), Vermeulen, Natasha, Duim, Wiebren, Kell, Douglas B.   +5 more
openaire   +2 more sources

Age Sensitivity of NFκB Abundance and Programmed Cell Death in Erythrocytes Induced by NFκB Inhibitors

Cellular Physiology and Biochemistry, 2013
Background/Aims: Erythrocytes may enter eryptosis, a suicidal death characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte outer membrane.
Mehrdad Ghashghaeinia, Judith C. Cluitmans, Mahmoud Toulany, Mohammad Saki, Martin Köberle, Elisabeth Lang, Peter Dreischer, Tilo Biedermann, Michael Duszenko, Florian Lang, Giel J. Bosman, Thomas Wieder   +11 more
doaj   +1 more source

Shear‐Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries

Small, Volume 22, Issue 52, 16 September 2026.
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E. Ingber, Zixiang Leonardo Liu, Netanel Korin   +10 more
wiley   +1 more source

Impact of Cyclin-Dependent Kinase CDK4 Inhibition on Eryptosis [PDF]

, 2015
Background/Aims: The cyclin-dependent kinase 4 (CDK4) participates in the regulation of apoptosis of nucleated cells by altering transcriptional regulation of genes governing cell proliferation and cell death.
Lang, F., Lang, E., Anand Rotte, Syed M. Qadri, Qadri, S.M., Mehrdad Ghashghaeinia, Adrian Lupescu, Elisabeth Lang, Zelenak, C., Rosi Bissinger, Florian Lang, Lupescu, A., Matthias Eberhard, Ghashghaeinia, M., Christine Zelenak, Eberhard, M., Bissinger, R., Rotte, A.   +17 more
core   +1 more source