Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The alkylphospholipid perifosine is used for the treatment of malignancy. The substance is effective by triggering suicidal tumor cell death or apoptosis. Side effects of perifosine include anemia. At least in theory, perifosine-induced anemia could result from stimulation of suicidal erythrocyte death or eryptosis.
Jasmin Egler, Florian Lang
core +7 more sources
Computerized Morphometric Analysis of Eryptosis [PDF]
Frontiers in Physiology, 2019 Eryptosis is the suicidal destruction-process of erythrocytes, much like apoptosis of nucleated cells, in the course of which the stressed red cell undergoes cell-shrinkage, vesiculation and externalization of membrane phosphatidylserine.
Sanu Susan Jacob +7 more
doaj +3 more sources
Vitamin C Inhibits Aggravated Eryptosis by Hydrogen Peroxide in Glucose-6-Phosphated Dehydrogenase Deficiency [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: The study was aimed to investigate if vitamin C could exert protective effects on development of eryptosis caused by glucose-6-phosphate dehydrogenase (G6PD) deficiency and hydrogen peroxide. Methods: Isolated erythrocytes with different
Feng Shan +3 more
doaj +2 more sources
Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia [PDF]
Cellular Physiology and Biochemistry, 2016 Background: The progression of systemic lupus erythematosus (SLE) leads to anemia in patients, adversely affecting prognosis. The diverse causes of anemia may include excessive eryptosis or premature suicidal erythrocyte death characterized by cell ...
Peipei Jiang +11 more
doaj +2 more sources
Simvastatin, a Novel Stimulator of Eryptosis, the Suicidal Erythrocyte Death [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: The 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase inhibitor simvastatin has been shown to trigger apoptosis of several cell types. The substance has thus been proposed as an additional treatment of malignancy.
Abdulla Al Mamun Al Mamun Bhuyan +4 more
doaj +2 more sources
Red Blood Cell Glycation Triggers In Vivo Cerebral Erythrophagocytosis in Adult Zebrafish in a Model Mimicking Hemorrhagic Stroke. [PDF]
Compr PhysiolIn zebrafish, glycated RBCs promoted increased erythrophagocytic activity in microglia/macrophages, revealing a potential mechanism linking diabetes‐induced RBC glycation to exacerbated inflammatory responses and secondary damage after ICH. ABSTRACT Hemorrhagic stroke, particularly intracerebral hemorrhage (ICH), is a highly lethal subtype of stroke ...
Morello E +7 more
europepmc +2 more sources
The Cytotoxic Effect of Septic Plasma on Healthy RBCs: Is Eryptosis a New Mechanism for Sepsis? [PDF]
International Journal of Molecular Sciences, 2023 Grazia Maria, , Luca Sgarabotto
exaly +2 more sources
Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion-dependent β-thalassaemia. [PDF]
Br J HaematolSummary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Theocharaki K +8 more
europepmc +2 more sources
Physiology and Pathophysiology of Eryptosis [PDF]
Transfusion Medicine and Hemotherapy, 2012 Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Eryptotic cells adhere to the vascular wall and are rapidly cleared from circulating blood. Eryptosis is stimulated by an increase in cytosolic Ca(2)+ activity,
Florian, Lang +2 more
openaire +2 more sources
Suicidal Erythrocyte Death in Metabolic Syndrome
Antioxidants, 2021 Eryptosis is a coordinated, programmed cell death culminating with the disposal of cells without disruption of the cell membrane and the release of endocellular oxidative and pro-inflammatory milieu.
Ignazio Restivo +3 more
doaj +1 more source