Results 1 to 10 of about 4,109 (159)

Stimulation of Erythrocyte Cell Membrane Scrambling by Mushroom Tyrosinase [PDF]

Toxins, 2014
Background: Mushroom tyrosinase, a copper containing enzyme, modifies growth and survival of tumor cells. Mushroom tyrosinase may foster apoptosis, an effect in part due to interference with mitochondrial function.
Leonie Frauenfeld, Kousi Alzoubi, Majed Abed, Florian Lang   +3 more
doaj   +7 more sources

A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane. [PDF]

Proc Natl Acad Sci U S A
The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner leaflet, and phosphatidylcholine mostly on the outer leaflet, is maintained by ATP-dependent flippases and floppases that exhibit headgroup selectivity.
Teo CF, Tuomivaara ST, van Hilten N, Crottès D, Jan YN, Grabe M, Jan LY.   +6 more
europepmc   +9 more sources

Triggering of Erythrocyte Cell Membrane Scrambling by Emodin [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: The natural anthraquinone derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a component of several Chinese medicinal herbal preparations utilized for more than 2000 years. The substance has been used against diverse disorders
Morena Mischitelli, Mohamed Jemaà, Mustafa Almasry, Caterina Faggio, Florian Lang   +4 more
doaj   +4 more sources

Inhibition of Erythrocyte Cell Membrane Scrambling by ASP3026 [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: The anaplastic lymphoma kinase (ALK) inhibitor ASP3026 is in clinical development for the treatment of ALK expressing non-small cell lung carcinoma (NSCLC). ASP3026 is in part effective by inducing apoptosis of tumor cells.
Abdulla Al Mamun Bhuyan, Rosi Bissinger, Hang Cao, Florian Lang   +3 more
doaj   +4 more sources

Investigation of Phosphatidylserine-Transporting Activity of Human TMEM16C Isoforms

Membranes, 2022
Lipid scrambling is a rapid process that dissipates the asymmetrical distribution of phospholipids in the plasma membrane. It is involved in various physiological functions such as blood coagulation and apoptosis.
Hanggu Kim, Eunyoung Kim, Byoung-Cheol Lee   +2 more
doaj   +2 more sources

Development of membrane-insertable lipid scrambling peptides: A time-resolved small-angle neutron scattering study

Structural Dynamics, 2021
Phospholipid transbilayer movement (flip-flop) in the plasma membrane is regulated by membrane proteins to maintain cell homeostasis and interact with other cells.
Hiroyuki Nakao, Yusuke Kimura, Ami Sakai, Keisuke Ikeda, Minoru Nakano   +4 more
doaj   +2 more sources

Stimulation of Platelet Death by Vancomycin

Cellular Physiology and Biochemistry, 2013
Background/Aims: Side effects of vancomycin, a widely used antibiotic, include thrombocytopenia. The vancomycin-induced thrombocytopenia has been attributed to immune reactions.
Syeda T. Towhid, Eva-Maria Schmidt, Alexander Tolios, Patrick Münzer, Evi Schmid, Oliver Borst, Meinrad Gawaz, Evi Stegmann, Florian Lang   +8 more
doaj   +2 more sources

Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: The streptomycete derived farnesyltransferase inhibitor Manumycin A triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy.
Jasmin Egler, Jens Zierle, Florian Lang
doaj   +2 more sources

Lactose Permease Scrambles Phospholipids

Biology, 2023
Lactose permease (LacY) from Escherichia coli belongs to the major facilitator superfamily. It facilitates the co-transport of β-galactosides, including lactose, into cells by using a proton gradient towards the cell.
Lei Wang, Peter Bütikofer
doaj   +1 more source

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

Cell Reports, 2020
Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu, Vitalij Cernysiov, Dominique Davidson, Hua Song, Jianlong Tang, Shanshan Luo, Yan Lu, Jin Qian, Ivayla E. Gyurova, Stephen N. Waggoner, Vincent Quoc-Huy Trinh, Romain Cayrol, Ayumu Sugiura, Heidi M. McBride, Jean-François Daudelin, Nathalie Labrecque, André Veillette   +16 more
doaj   +1 more source