Results 1 to 10 of about 19,858 (214)

SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation.

PLoS ONE, 2016
Dengue virus (DENV) infection causes organ injuries, and the liver is one of the most important sites of DENV infection, where viral replication generates a high viral load.
Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Aunchalee Sirimontaporn, Jutatip Panaampon, Sansanee Noisakran, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn   +6 more
doaj   +2 more sources

P38 MAPK Pharmacological Inhibitor SB203580 Alleviates Total Parenteral Nutrition-Induced Loss of Intestinal Barrier Function but Promotes Hepatocyte Lipoapoptosis

Cellular Physiology and Biochemistry, 2017
Background & Aims: Our previous studies have provided evidence that p38 mitogen-activated protein kinase (MAPK) is involved in total parenteral nutrition (TPN)-associated complications, but its exact effects and mechanisms have not been fully ...
Jun-Kai Yan, Wei Cai
exaly   +3 more sources

Role of the MAPK pathway in human lung epithelial-like A549 cells apoptosis induced by paraquat [PDF]

Genetics and Molecular Biology, 2020
This study aims to investigate the value of mitogen-activated protein kinases (MAPKs) for paraquat (PQ)-induced apoptosis in human lung epithelial-like A549 cells and the specific mechanism. A549 cell apoptosis were induced by PQ.
Da-Zhuang Sun, Chun-Qing Song, Yong-Min Xu, Xue-Song Dong   +3 more
doaj   +1 more source

Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella. [PDF]

PLoS ONE, 2015
E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38 ...
Françoise I Bussière, Fabien Brossier, Yves Le Vern, Alisson Niepceron, Anne Silvestre, Thibaut de Sablet, Sonia Lacroix-Lamandé, Fabrice Laurent   +7 more
doaj   +1 more source

APPLICATION OF INHIBITOR ANALYSIS FOR STUDYING MECHANISMS AND ACTIONS OF POLYMURAMYL, A MURAMYL PEPTIDE-BASED IMMUNE MODULATOR

Медицинская иммунология, 2014
In present study, the following low-MW inhibitors were used to dissect mechanisms of action for two muramyl peptide components of Polymuramyl, an immunomodulatory drug: (1) N-acetyl-D-glucosaminyl-(β1→4)-N-acetyl-D-muramoyl-L-alanyl-D-isoglutaminyl-meso ...
M. V. Pashenkov, B. I. Alkhazova, V. L. L'vov, B. V. Pinegin   +3 more
doaj   +1 more source

Inhibition of p38 Mitogen-Activated Protein Kinase Impairs Mayaro Virus Replication in Human Dermal Fibroblasts and HeLa Cells

Viruses, 2021
Mayaro virus (MAYV) hijacks the host’s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK1/2 have emerged as crucial cellular factors implicated in different stages of the viral cycle.
Madelaine Sugasti-Salazar, Yessica Y. Llamas-González, Dalkiria Campos, José González-Santamaría   +3 more
doaj   +1 more source

Inhibition of p38 MAPK Signaling Regulates the Expression of EAAT2 in the Brains of Epileptic Rats

Frontiers in Neurology, 2018
Seizures induce the release of excitatory amino acids (EAAs) from the intracellular fluid to the extracellular fluid, and the released EAAs primarily comprise glutamic acid (Glu) and asparaginic acid (Asp).
Zhang Yang, Zhang Yang, Jing Wang, Changyin Yu, Ping Xu, Jun Zhang, Yan Peng, Zhong Luo, Hao Huang, Junwei Zeng, Zucai Xu, Zucai Xu   +11 more
doaj   +1 more source

SB203580, a p38MAPK inhibitor, attenuates olfactory dysfunction by inhibiting OSN apoptosis in AR mice (activation and involvement of the p38 mitogen‐activated protein kinase in olfactory sensory neuronal apoptosis of OVA‐induced allergic rhinitis)

Brain and Behavior, 2019
Objective This study aimed to investigate the effect of the p38 mitogen‐activated protein kinase (p38MAPK) signaling pathway on olfactory mucosa function and apoptosis of olfactory sensory neurons (OSNs) in an allergic rhinitis (AR) mouse model.
Xian Gao, Na Li, Jisheng Zhang
doaj   +1 more source

Upregulation of Chemoresistance by Mg²⁺ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells

Cells, 2021
Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg2+ deficiency affects chemosensitivity of cancer cells.
Saki Onuma, Aya Manabe, Yuta Yoshino, Toshiyuki Matsunaga, Tomohiro Asai, Akira Ikari   +5 more
doaj   +1 more source

The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju, ZHANG Ge , WANG Xiao⁃jing, XING Xiao⁃min, MA Guo⁃zhao   +4 more
doaj   +1 more source