Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580 [PDF]
FEBS Letters, 1999 SB203580 (4‐(4‐fluorophenyl)‐2‐(4‐methylsulfinylphenyl)‐5‐(4‐pyridyl)1H‐imidazole) is widely used as a specific inhibitor of p38 mitogen‐activated protein kinase (MAPK). Here, we report that SB203580 activates the serine/threonine kinase Raf‐1 in quiescent smooth muscle cells in a dose‐dependent fashion.
Alexander W Clowes +2 more
exaly +3 more sources
Norepinephrine inhibits cell cycle re‐entry of neonatal rat ventricular cardiomyocytes characterized by the absence of de novo nestin expression [PDF]
Physiological ReportsThe p38α/β MAPK inhibitor SB203580 in the presence of a phorbol ester (protein kinase C activator) induced cell cycle re‐entry of two subpopulations of neonatal rat ventricular cardiomyocytes (NNVMs) distinguished by the absence or de novo nestin ...
Adrien Aubry +4 more
doaj +2 more sources
In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580
International Journal of COPD, 2016 Aihong Meng,1 Xiaopeng Zhang,2 Siyu Wu,1 Mingxia Wu,1 Jing Li,1 Xixin Yan,1 Kamilla Kopec-Harding,3 Jiakai Wu41Respiratory Division, The Second Hospital of Hebei Medical University, 2Department of Thoracic Surgery, Hebei Province General Hospital ...
Meng AH +7 more
doaj +1 more source
The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway [PDF]
Frontiers in PharmacologyBackgroundAcorus tatarinowii Schott holds a prominent position in Traditional Chinese Medicine, with its earliest record found in the ancient Chinese pharmacopeia, the Shennong’s Classic of Materia Medica.
Xing Wei +17 more
doaj +2 more sources
Role of the MAPK pathway in human lung epithelial-like A549 cells apoptosis induced by paraquat [PDF]
Genetics and Molecular Biology, 2020 This study aims to investigate the value of mitogen-activated protein kinases (MAPKs) for paraquat (PQ)-induced apoptosis in human lung epithelial-like A549 cells and the specific mechanism. A549 cell apoptosis were induced by PQ.
Da-Zhuang Sun +3 more
doaj +1 more source
Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella. [PDF]
PLoS ONE, 2015 E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38 ...
Françoise I Bussière +7 more
doaj +1 more source
SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma [PDF]
International Journal of Molecular Sciences, 2021 Subepithelial fibrosis is a component of the remodeling observed in the bronchial wall of patients diagnosed with asthma. In this process, human bronchial fibroblasts (HBFs) drive the fibroblast-to-myofibroblast transition (FMT) in response to transforming growth factor-β1 (TGF-β1), which activates the canonical Smad-dependent signaling.
Milena Paw +7 more
openaire +3 more sources
Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus [PDF]
BioMed Research International, 2014 The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF)αin the hypothalamus of ewes during prolonged inflammation. Inflammation was induced by the administration of lipopolysaccharide (LPS) (400 ng/kg) over 7 days.
Andrzej P. Herman +5 more
openaire +2 more sources
In vitro modeling of COPD inflammation and limitation of p38 inhibitor - SB203580.
International journal of chronic obstructive pulmonary disease, 2016 Systemic inflammation and steroid resistance are the hallmarks of COPD. We examined the impact of p38 inhibitor (SB203580) in in vitro assays of systemic inflammation using pulmonary cells and patients' sera.Data from 66 COPD patients and 15 age-/sex-matched healthy controls were compared.
Meng, Aihong +7 more
openaire +4 more sources
Медицинская иммунология, 2014 In present study, the following low-MW inhibitors were used to dissect mechanisms of action for two muramyl peptide components of Polymuramyl, an immunomodulatory drug: (1) N-acetyl-D-glucosaminyl-(β1→4)-N-acetyl-D-muramoyl-L-alanyl-D-isoglutaminyl-meso ...
M. V. Pashenkov +3 more
doaj +1 more source