Results 21 to 30 of about 19,858 (214)

2-Hydroxyethyl Methacrylate Increases MMP-1 and MMP-3 Production in Human Gingival Fibroblasts. [PDF]

J Biochem Mol Toxicol
HEMA induces the production of MMP‐1 and MMP‐3 in human gingival fibroblasts by activating the p38 MAPK, JNK, and Akt signaling pathways. ABSTRACT 2‐Hydroxyethyl methacrylate (HEMA), a monomer commonly used in dental resin materials, has been reported to leach from polymerized resins.
Okamoto R, Hosokawa Y, Hosokawa I, Fukui A, Miyake N, Ozaki K, Hosaka K.   +6 more
europepmc   +2 more sources

Investigation of anticancer effect SB203580 and Ginnalin A on hepatocelluler carcinoma (HCC) cell line [PDF]

, 2018
Yüksek Lisans TeziInsan populasyonunda en sık görülen kanser tiplerinden biri olan hepatosellüler karsinoma (HCC) klinik olarak kullanılan kemoterapötik ve radyoterapötik ajanlara direncin gözlendiği ve tedavi seçeneklerinin kısıtlı olduğu kanser ...
Özden, Pınar
core   +2 more sources

Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway. [PDF]

PLoS ONE, 2014
Transdifferentiation of human Tenon fibroblasts to myofibroblasts and subsequent deposition of extracellular matrix is a key step in the scarring after glaucoma filtration surgery.
Yong-Heng Luo, Ping-Bo Ouyang, Jiao Tian, Xiao-Jian Guo, Xuan-Chu Duan   +4 more
doaj   +1 more source

Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation

ADMET and DMPK, 2015
The aim of this study was to evaluate the effects of the mitogen-activated protein kinase (MAPK) pathway inhibitors SB203580, CMPD-1, SB239063, SP600125, and FR180204 on the activity of P-glycoprotein (P-gp) and to assess whether the MAPK pathway affects
Hirokazu Wakuda, Shino Miyauchi, Kana Maruyama, Satomi Kagota, Kazuki Nakamura, Keizo Umegaki, Shizuo Yamada, Kazumasa Shinozuka   +7 more
doaj   +1 more source

The p38 MAPK-specific inhibitor SB203580 inhibited NO and TNF-α production by suppressing NF-κB and AP-1 activities.

, 2014
(A) BV2 cells were treated with LPS for 16 h in the absence or presence of SB203580, and released NO and TNF-α were measured as previously described. Bars indicate the mean ± S.E.M.
Young Sun Chung (521763), Hee-Sun Kim (199700), Heebum Song (521762), Seung Bum Park (197493), Yeon-Hui Jeong (521760), Yongju Kim (521761)   +5 more
core   +1 more source

Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo

Mediators of Inflammation, 2013
p38 mitogen-activated protein kinase (MAPK) signalling is critical in the pathophysiology of a variety of inflammatory processes. Leukocyte recruitment to the site of inflammation is a multistep process governed by specific signalling cascades.
Najia Xu, Mokarram Hossain, Lixin Liu
doaj   +1 more source

p38 mitogen-activated protein kinase independent SB203580 block of H2O2-induced increase in GABAergic mIPSC amplitude [PDF]

NeuroReport, 2007
Hydrogen peroxide may serve as a diffusible intermediary messenger under physiological and pathophysiological conditions. H2O2 (1 mM) increased the amplitude of GABAergic miniature inhibitory postsynaptic currents in substantia gelatinosa of the spinal cord.
Ayako, Takahashi, Maya, Mikami, Jay, Yang   +2 more
openaire   +2 more sources

SB203580 reduces cytokine secretion by inhibiting p38 phosphorylation.

, 2016
(A) In Ad-GPR4-FaDu cells, SB203580 reduced the expression of IL6, IL8 and VEGFA at pH 5.9. (B) SB203580 reduced secretion of IL6, IL8 and VEGFA. (C) GPR4 increased p38 phosphorylation at pH5.9.
Xiaohong Chen (220164), Yang Zhang (30734), Wei Guo (86150), Shuo Ding (3173940), Zhibin Jing (3173943), Hongbo Xu (748097), Ping Chen (89712), Qi Zhong (769240), Zheng Yang (264955), Zhigang Huang (541051), Junwei Huang (516190)   +10 more
core   +1 more source

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB

Mediators of Inflammation, 2017
Background. LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated the relationship between LBP and fractalkine in LPS-induced A549 cells and rat lung tissue in an ARDS rat model. Methods.
Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R. Sooranna, Liao Pinhu   +7 more
doaj   +1 more source

SB203580 decreases parasite motility.

, 2015
(A) Effect of SB203580 on sporozoite trail deposits during parasite gliding. Treatment: sporozoites placed on glass slides covered with gelatin were incubated for 1 h in the presence of SB203580 (25 μM) or DMSO.
Thibaut de Sablet (192383), Anne Silvestre (692734), Françoise I. Bussière (692733), Yves Le Vern (334998), Sonia Lacroix-Lamandé (238567), Alisson Niepceron (328723), Fabrice Laurent (238581), Fabien Brossier (249897)   +7 more
core   +1 more source