SB203580 reduces cytokine secretion by inhibiting p38 phosphorylation. [PDF]
, 2016 (A) In Ad-GPR4-FaDu cells, SB203580 reduced the expression of IL6, IL8 and VEGFA at pH 5.9. (B) SB203580 reduced secretion of IL6, IL8 and VEGFA. (C) GPR4 increased p38 phosphorylation at pH5.9.
Xiaohong Chen (220164) +10 more
core +1 more source
SB203580 decreases parasite micronemal protein secretion. [PDF]
, 2015 Treatment consisted in incubation of sporozoites for 2 h in complete cell culture medium with SB203580 (25 μM) or DMSO. Pre-treatment consisted in first incubating sporozoites with SB203580 (25 μM) or DMSO for 1 h.
Thibaut de Sablet (192383) +7 more
core +1 more source
SB203580 does not permanently alter parasite invasion. [PDF]
, 2015 Sporozoites were incubated for 1 h with SB203580 (25 μM); then, after chasing, sporozoites were incubated with cells for 2 h. Cell invasion was monitored and is represented as the percentage of infected cells compared to DMSO pre-treated-sporozoites ...
Thibaut de Sablet (192383) +7 more
core +1 more source
The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju +4 more
doaj +1 more source
Rosiglitazone and SB203580 suppressed the mRNA expression of α-SMA, Col I, and CTGF. [PDF]
, 2014 Fibroblasts were treated with rosiglitazone for 2 h or SB203580 for 1 h. Next, the cells were incubated with 5 ng/mL TGF-β1 in the presence of rosiglitazone or SB203580 for 12 h (for CTGF mRNA analysis) or 24 h (for α-SMA and Col I mRNA analysis ...
Xiao-Jian Guo (619451) +4 more
core +1 more source
Treatment with p38 MAPK inhibitor (SB203580) inhibits EV71 replication at the viral protein synthesis stage. [PDF]
, 2015 (A) Mock-infected RD cells were treated with SB203580 at different concentrations (10, 25, 50 and 100μM) or 1.0% DMSO (negative control) and cell lysates were harvested for Western blotting at 6h post-treatment. β-actin was included as a loading control.
Bryan Kit Teck Ong (699835) +2 more
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Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway. [PDF]
PLoS ONE, 2014 Transdifferentiation of human Tenon fibroblasts to myofibroblasts and subsequent deposition of extracellular matrix is a key step in the scarring after glaucoma filtration surgery.
Yong-Heng Luo +4 more
doaj +1 more source
Inhibitory effects of SP600125 and SB203580 on UVA-induced CatK expression. [PDF]
, 2014 Cells were pretreated with 800 µM SB203580 for 1 h, mock-irradiated or irradiated with 10 J/cm2 UVA, and then incubated in culture medium supplemented with MAPK inhibitors for 48 h. (A) Effects of SP600125 and SB203580 on UVA-induced CatK mRNA expression.
Qingfang Xu (601810) +7 more
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ADMET and DMPK, 2015 The aim of this study was to evaluate the effects of the mitogen-activated protein kinase (MAPK) pathway inhibitors SB203580, CMPD-1, SB239063, SP600125, and FR180204 on the activity of P-glycoprotein (P-gp) and to assess whether the MAPK pathway affects
Hirokazu Wakuda +7 more
doaj +1 more source
Rosiglitazone and SB203580 attenuated fibroblast proliferation induced by TGF-β1. [PDF]
, 2014 (A) Cell Counting Kit-8 assays showed that treatment with TGF-β1 significantly increased the proliferation of fibroblasts after 24 h (p0.05). The inhibitory effect of SB203580 on TGF-β1 stimulated cell proliferation was weaker than the effect of ...
Xiao-Jian Guo (619451) +4 more
core +1 more source