Results 31 to 40 of about 18,824 (215)

p38 mitogen-activated protein kinase independent SB203580 block of H2O2-induced increase in GABAergic mIPSC amplitude [PDF]

NeuroReport, 2007
Hydrogen peroxide may serve as a diffusible intermediary messenger under physiological and pathophysiological conditions. H2O2 (1 mM) increased the amplitude of GABAergic miniature inhibitory postsynaptic currents in substantia gelatinosa of the spinal cord.
Ayako, Takahashi, Maya, Mikami, Jay, Yang   +2 more
openaire   +2 more sources

Effect SB203580 of on Ox-LDL-induced mineralization in cultured VSMCs (n = 3). [PDF]

, 2013
Cells were grown in control medium (in DMSO), 50 µg/ml Ox-LDL alone (in DMSO), 50 µg/ml Ox-LDL supplemented with 5 µM SB203580 (in DMSO), 5 µM C2-ceramide alone (in DMSO) or 5 µM C2-ceramide supplemented with 5 µM SB203580 (in DMSO) for 24 hours.
Meihong Ye (498236), Yanling Chen (498235), Huimin Yu (498234), Yan Song (119387), Sheng Wang (339979), Lizhen Liao (498232), Lihe Lu (498237), Qin Zhou (239082), Weikang Wu (498233)   +8 more
core   +1 more source

Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo

Mediators of Inflammation, 2013
p38 mitogen-activated protein kinase (MAPK) signalling is critical in the pathophysiology of a variety of inflammatory processes. Leukocyte recruitment to the site of inflammation is a multistep process governed by specific signalling cascades.
Najia Xu, Mokarram Hossain, Lixin Liu
doaj   +1 more source

SB203580 does not reduce DENV production in DENV-infected mice. [PDF]

, 2016
Mice were infected with 4 × 105 FFU/ml of DENV and treated with 2%DMSO alone or SB203580 in 2%DMSO. The uninfected control group was also treated with 2%DMSO.
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB

Mediators of Inflammation, 2017
Background. LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated the relationship between LBP and fractalkine in LPS-induced A549 cells and rat lung tissue in an ARDS rat model. Methods.
Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R. Sooranna, Liao Pinhu   +7 more
doaj   +1 more source

The p38 MAPK-specific inhibitor SB203580 inhibited NO and TNF-α production by suppressing NF-κB and AP-1 activities. [PDF]

, 2014
(A) BV2 cells were treated with LPS for 16 h in the absence or presence of SB203580, and released NO and TNF-α were measured as previously described. Bars indicate the mean ± S.E.M.
Young Sun Chung (521763), Hee-Sun Kim (199700), Heebum Song (521762), Seung Bum Park (197493), Yeon-Hui Jeong (521760), Yongju Kim (521761)   +5 more
core   +1 more source

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Scientific Reports, 2017
2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity.
Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu   +5 more
doaj   +1 more source

Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins, 2016
Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis.
Ilona Schelle, Janina Bruening, Mareike Buetepage, Harald Genth   +3 more
doaj   +1 more source

Chronic treatment with TNF-α, alone and in combination with Takinib, SB203580 and metformin induce cell death in breast cancer

Heliyon, 2023
Breast cancer (BC) is the most common malignancy, and the largest cause of cancer death among women. The interactions between tumor cells and tumor micro environmental factors have a major impact on tumor progression. One of the critical pro-inflammatory
Maryam Abdolvand, Milad Shahini Shams Abadi, Amin Soltani, Fatemeh Banisharif, Mahdi Ghatrehsamani   +4 more
doaj   +1 more source

p38 MAP kinase inhibitor suppresses transforming growth factor-β2-induced type 1 collagen production in trabecular meshwork cells.

PLoS ONE, 2015
Glaucoma is an age-related neurodegenerative disease of retinal ganglion cells, and appropriate turnover of the extracellular matrix in the trabecular meshwork is important in its pathology. Here, we report the effects of Rho-associated kinase (ROCK) and
Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto, Takanori Kameda, Nanako Awai-Kasaoka, Naoki Ohtsu, Kenichi Kimoto, Hidenobu Tanihara   +7 more
doaj   +1 more source