Results 51 to 60 of about 15,652 (174)

P38 Phosphorylation in Medullary Microglia Mediates Ectopic Orofacial Inflammatory Pain in Rats

Molecular Pain, 2015
Background Orofacial inflammatory pain is likely to accompany referred pain in uninflamed orofacial structures. The ectopic pain precludes precise diagnosis and makes treatment problematic, because the underlying mechanism is not well understood.
Masaaki Kiyomoto, Masamichi Shinoda, Kuniya Honda, Yuka Nakaya, Ko Dezawa, Ayano Katagiri, Satoshi Kamakura, Tomio Inoue, Koichi Iwata   +8 more
doaj   +1 more source

Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: The streptomycete derived farnesyltransferase inhibitor Manumycin A triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy.
Jasmin Egler, Jens Zierle, Florian Lang
doaj   +1 more source

Cryptocaryone Exhibits ROS/MAPK‐Dependent Antiproliferative and Apoptosis‐Inducing Effects on Triple‐Negative Breast Cancer Cells and Proof‐of‐Concept Breast Cancer Mouse Model

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Omics’ technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple‐negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not respond well to current targeted therapies.
Ya‐Ting Chuang, Wangta Liu, Tsu‐Ming Chien, Ammad Ahmad Farooqi, Hsun‐Shuo Chang, Jun‐Ping Shiau, Hsueh‐Wei Chang   +6 more
wiley   +1 more source

Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling

Drug Design, Development and Therapy, 2019
Jian-Wei Lin,1 Le-He Yang,2 Zhuo-Chao Ren,3 De-Guang Mu,3 Ya-Qing Li,3 Jian-Ping Yan,3 Liang-Xing Wang,4 Chun Chen31Department of Cardiology, Xiasha Campus, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310018, Zhejiang ...
Lin JW, Yang LH, Ren ZC, Mu DG, Li YQ, Yan JP, Wang LX, Chen C   +7 more
doaj  

p38 Mitogen-Activated Protein Kinase Contributes to Angiotensin II-Stimulated Migration of Rat Aortic Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee, Chang-Kwon Lee, So Hee Lee, Hui Yul Roh, Young Min Bae, Kyung-Yung Lee, Jaegeun Lim, Pyo-Jam Park, Tae-Kyu Park, Yun Lyul Lee, Kyung-Jong Won, Bokyung Kim   +11 more
doaj   +1 more source

Effect of SB203580 on apoptosis related gene expression pattern of SEB in human PBMCs

The FASEB Journal, 2009
Here we attempt to utilize a well characterized set of apoptotic related genes that are key to the pathogenesis of Staphylococcal Enterotoxin B (SEB) induced lethal shock in human peripheral blood mononuclear cells (PBMC) to evaluate the effectiveness of a potential inhibitor of apoptosis related events.
Tricia Nicole Mason, Aaron Matthew Hopkins, Chanaka Mendis   +2 more
openaire   +1 more source

Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580 [PDF]

Journal of Biological Chemistry, 2003
The proximal promoter sequence of the interleukin-2 (IL-2) gene contains a series of composite sites or modules that controls much of its responsiveness to environmental stimuli. The integrated targeting of these modules is therefore a major mode of regulation.
James L, Smith, Irene, Collins, G V R, Chandramouli, Wayne G, Butscher, Elena, Zaitseva, Wendy J, Freebern, Cynthia M, Haggerty, Victoria, Doseeva, Kevin, Gardner   +8 more
openaire   +2 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, Volume 36, Issue 24, 23 March 2026.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Dual inhibition of DNA damage repair sensitizes photodynamic therapy for triple negative breast cancer

Materials Today Bio
Photodynamic therapy (PDT) has emerged as an ideal candidate among reactive oxygen species (ROS)-mediated tumor therapies. However, the self-repair of DNA, a hallmark of mechanism induced by excessive intracellular ROS is one of the leading causes of PDT
Yanting Sun, Mengyao Chen, Pingting Ye, Jingxian Yang, Kang Fang, Chunhui Wang, Ruihao Li, Ting Fan, Shuo Shi, Chunyan Dong   +9 more
doaj   +1 more source

Reversal of Adrenergic Desensitization in Prenatally Stressed Rats by P38 Map Kinase Inhibitor, SB203580

The FASEB Journal, 2008
We previously reported a defect in beta adrenergic responsiveness in cardiac myoctes isolated from pre‐natally stressed rats (PS) following restraint stress (R) (PS+R). We now report a reversal of the blunted beta adrenergic responsiveness in PS + R with the P38 MAP kinase inhibitor, SB203580, in vivo.
Fangping Chen, Hong Kan, Sherry Xie, Robert J Beto, Bradford E Warden, Abnash C Jain, Mitchell S Finkel   +6 more
openaire   +1 more source