Results 51 to 60 of about 18,824 (215)
Rosiglitazone and SB203580 suppressed the protein expression of α-SMA, Col I, and CTGF. [PDF]
, 2014 Fibroblasts were treated with rosiglitazone for 2 h or SB203580 for 1 h. Next, the cells were incubated with 5 ng/mL TGF-β1 in the presence of rosiglitazone or SB203580 for 24 h (for CTGF analysis) or 48 h (for α-SMA and Col I analysis).
Xiao-Jian Guo (619451) +4 more
core +1 more source
Сучасні медичні технологіїTranscriptional changes in organism and muscles especially during development of metabolic syndrome (MetS) is still highly understudied. Role of p38 MAPK activation during MetS is highly debatable.
O. Ye. Akimov, A. O. Mykytenko
doaj +1 more source
Allergy, EarlyView.IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama +16 more
wiley +1 more source
Central European Journal of Immunology, 2015 The p38 mitogen-activated protein kinase (MAPK) plays a key role in lipopolysaccharide (LPS)-induced signal transduction pathways that lead to inflammatory cytokine synthesis in macrophages; however, whether the inhibition of p38 MAPK regulates LPS-induced inflammatory cytokine expression in different types of macrophages remains the subject of debate.
Shi, Qinghai +6 more
openaire +2 more sources
Immunoblot analysis of caspase 3 and hepatocytes viability in response to SB203580 and SP600125. [PDF]
, 2013 Hepatyocytes were pre-treated with 10 µM SB203580 and SP600125 for 15 min, then treated with As (10 µM), taurine (25 mM, added 1 h prior to As treatment) for 8 h.
Joydeep Das (361941) +3 more
core +1 more source
Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells [PDF]
BMB Reports, 2012 Although previous studies have demonstrated that BMP9 is highlycapable of inducing osteogenic differentiation of mesenchymalstem cells, the molecular mechanism involved remains to be fullyelucidated.
Dao-jing Xu +5 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 This study aimed to investigate the regulatory role of Aldo-keto reductase family 1 member B1 (AKR1B1) in glioma cell proliferation through p38 MAPK activation to control Bcl-2/BAX/caspase-3 apoptosis signaling. AKR1B1 expression was quantified in normal
Yu-Kai Huang +4 more
doaj +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Investigation of anticancer effect SB203580 and Ginnalin A on hepatocelluler carcinoma (HCC) cell line [PDF]
, 2018 Yüksek Lisans TeziInsan populasyonunda en sık görülen kanser tiplerinden biri olan hepatosellüler karsinoma (HCC) klinik olarak kullanılan kemoterapötik ve radyoterapötik ajanlara direncin gözlendiği ve tedavi seçeneklerinin kısıtlı olduğu kanser ...
Özden, Pınar
core +1 more source
Inhibitory effects of SP600125 and SB203580 on UVA-activated MAPK pathway. [PDF]
, 2014 Cells were pretreated with 800 µM SB203580 for 1 h, mock-irradiated or irradiated with 10 J/cm2 UVA, and then incubated in culture medium supplemented with MAPK inhibitors for 1.5 h.
Qingfang Xu (601810) +7 more
core +1 more source