Results 51 to 60 of about 19,858 (214)
Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells [PDF]
BMB Reports, 2012 Although previous studies have demonstrated that BMP9 is highlycapable of inducing osteogenic differentiation of mesenchymalstem cells, the molecular mechanism involved remains to be fullyelucidated.
Dao-jing Xu +5 more
doaj +1 more source
Cancer Science, EarlyView.Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang +5 more
wiley +1 more source
The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells
Journal of Experimental & Clinical Cancer Research, 2010 Objectives To explore the function of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells, and discuss the signal transduetion mechanism of HepG2 cells in the apoptosis process induced by DADS by using the inhibitors of p38MAPK (SB203580)
Ma Heng +3 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 This study aimed to investigate the regulatory role of Aldo-keto reductase family 1 member B1 (AKR1B1) in glioma cell proliferation through p38 MAPK activation to control Bcl-2/BAX/caspase-3 apoptosis signaling. AKR1B1 expression was quantified in normal
Yu-Kai Huang +4 more
doaj +1 more source
International Journal of Cosmetic Science, EarlyView.Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak +5 more
wiley +1 more source
NOX2 silencing suppresses the growth of A431 xenografts treated with SB203580.
, 2014 The in vivo tumor growth of NOX2 knockdown A431 cells subcutaneously injected into NOG mice, which were either treated or not treated with SB203580 (SB+shNOX2 or shNOX2, respectively). A431 cells were transduced three days prior to injection.
Jung Ho Back (563606) +11 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck +13 more
wiley +1 more source
, 2019 International audienceDiabetic cardiomyopathy, especially myocardial ischemia reperfusion (I/R) injury, is a major cause of morbidity and mortality in type 2 diabetic patients.
Kumphune, Sarawut +9 more
core +1 more source
Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin
The Journal of Physiology, EarlyView.Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George +5 more
wiley +1 more source
SB203580 does not permanently alter parasite invasion.
, 2015 Sporozoites were incubated for 1 h with SB203580 (25 μM); then, after chasing, sporozoites were incubated with cells for 2 h. Cell invasion was monitored and is represented as the percentage of infected cells compared to DMSO pre-treated-sporozoites ...
Thibaut de Sablet (192383) +7 more
core +1 more source