Results 61 to 70 of about 19,858 (214)

Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling

Drug Design, Development and Therapy, 2019
Jian-Wei Lin,1 Le-He Yang,2 Zhuo-Chao Ren,3 De-Guang Mu,3 Ya-Qing Li,3 Jian-Ping Yan,3 Liang-Xing Wang,4 Chun Chen31Department of Cardiology, Xiasha Campus, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310018, Zhejiang ...
Lin JW, Yang LH, Ren ZC, Mu DG, Li YQ, Yan JP, Wang LX, Chen C   +7 more
doaj  

P38 Phosphorylation in Medullary Microglia Mediates Ectopic Orofacial Inflammatory Pain in Rats

Molecular Pain, 2015
Background Orofacial inflammatory pain is likely to accompany referred pain in uninflamed orofacial structures. The ectopic pain precludes precise diagnosis and makes treatment problematic, because the underlying mechanism is not well understood.
Masaaki Kiyomoto, Masamichi Shinoda, Kuniya Honda, Yuka Nakaya, Ko Dezawa, Ayano Katagiri, Satoshi Kamakura, Tomio Inoue, Koichi Iwata   +8 more
doaj   +1 more source

Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: The streptomycete derived farnesyltransferase inhibitor Manumycin A triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy.
Jasmin Egler, Jens Zierle, Florian Lang
doaj   +1 more source

Evidence for the involvement of p38 MAPK activation in barnacle larval settlement. [PDF]

PLoS ONE, 2012
The barnacle Balanus ( = Amphibalanus) amphitrite is a major marine fouling animal. Understanding the molecular mechanism of larval settlement in this species is critical for anti-fouling research.
Li-Sheng He, Ying Xu, Kiyotaka Matsumura, Yu Zhang, Gen Zhang, Shu-Hua Qi, Pei-Yuan Qian   +6 more
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Effect of SB203580 on apoptosis related gene expression pattern of SEB in human PBMCs

The FASEB Journal, 2009
Here we attempt to utilize a well characterized set of apoptotic related genes that are key to the pathogenesis of Staphylococcal Enterotoxin B (SEB) induced lethal shock in human peripheral blood mononuclear cells (PBMC) to evaluate the effectiveness of a potential inhibitor of apoptosis related events.
Tricia Nicole Mason, Aaron Matthew Hopkins, Chanaka Mendis   +2 more
openaire   +1 more source

Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580 [PDF]

Journal of Biological Chemistry, 2003
The proximal promoter sequence of the interleukin-2 (IL-2) gene contains a series of composite sites or modules that controls much of its responsiveness to environmental stimuli. The integrated targeting of these modules is therefore a major mode of regulation.
James L, Smith, Irene, Collins, G V R, Chandramouli, Wayne G, Butscher, Elena, Zaitseva, Wendy J, Freebern, Cynthia M, Haggerty, Victoria, Doseeva, Kevin, Gardner   +8 more
openaire   +2 more sources

Inhibitory effects of SP600125 and SB203580 on UVA-induced CatK expression.

, 2014
Cells were pretreated with 800 µM SB203580 for 1 h, mock-irradiated or irradiated with 10 J/cm2 UVA, and then incubated in culture medium supplemented with MAPK inhibitors for 48 h. (A) Effects of SP600125 and SB203580 on UVA-induced CatK mRNA expression.
Qingfang Xu (601810), Chen Liu (75209), Chun Lu (107478), Howard I. Maibach (601814), Yue Zheng (601811), Wei Hou (48073), Zijian Gong (601812), Wei Lai (601813)   +7 more
core   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Descriptive data from studied CD-1 pregnant mice according to treatments groups (n = 5 animals/group): Saline, Cont-Oligo, T-oligo and T-oligo co-treatment with SB203580.

, 2015
(g: grams; SB203580: p38MAPK inhibitor)*Anova, Tukey's Multiple Comparison Test, p = 0.001.Descriptive data from studied CD-1 pregnant mice according to treatments groups (n = 5 animals/group): Saline, Cont-Oligo, T-oligo and T-oligo co-treatment with ...
Robert N. Taylor (333093), Brandie D. Taylor (798894), Jossimara Polettini (502572), George R. Saade (502573), Ramkumar Menon (201971), Faranak Behnia (798893)   +5 more
core   +1 more source