Results 61 to 70 of about 18,824 (215)

The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells

Journal of Experimental & Clinical Cancer Research, 2010
Objectives To explore the function of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells, and discuss the signal transduetion mechanism of HepG2 cells in the apoptosis process induced by DADS by using the inhibitors of p38MAPK (SB203580)
Ma Heng, Ren Fenglian, Ji Chunxiao, Xu Ming   +3 more
doaj   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

SB203580 and ruxolitinib attenuated the effects of rAIF-1 on A549 cell proliferation, migration, and production of IL-6 and VEGF. [PDF]

, 2022
(A) Culture medium levels of IL-6 secreted by A549 cells. Ru: Ruxolitinib; SB: SB203580. Data are shown as mean ± SD. *** P P B) Culture medium levels of VEGF secreted by A549 cells. Ru: Ruxolitinib; SB: SB203580. Data are shown as mean ± SD.
Cuimin Zhu (12116799), Lingling Wang (66269), Yanhong Liu (124527), Xing Zhao (219333), Huachuan Zheng (14266110)   +4 more
core   +1 more source

Evidence for the involvement of p38 MAPK activation in barnacle larval settlement. [PDF]

PLoS ONE, 2012
The barnacle Balanus ( = Amphibalanus) amphitrite is a major marine fouling animal. Understanding the molecular mechanism of larval settlement in this species is critical for anti-fouling research.
Li-Sheng He, Ying Xu, Kiyotaka Matsumura, Yu Zhang, Gen Zhang, Shu-Hua Qi, Pei-Yuan Qian   +6 more
doaj   +1 more source

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

NOX2 silencing suppresses the growth of A431 xenografts treated with SB203580. [PDF]

, 2014
The in vivo tumor growth of NOX2 knockdown A431 cells subcutaneously injected into NOG mice, which were either treated or not treated with SB203580 (SB+shNOX2 or shNOX2, respectively). A431 cells were transduced three days prior to injection.
Jung Ho Back (563606), Houssam Raad (371435), Liang Liu (50022), Mohammad Athar (156040), Yucui Zhu (563608), Hamid Reza Rezvani (563605), Xiuwei Tang (156027), Arianna L. Kim (156033), Mohsen Hosseini (563607), Walid Mahfouf (372883), Grace Raji (563609), David R. Bickers (156037)   +11 more
core   +1 more source

P38 Phosphorylation in Medullary Microglia Mediates Ectopic Orofacial Inflammatory Pain in Rats

Molecular Pain, 2015
Background Orofacial inflammatory pain is likely to accompany referred pain in uninflamed orofacial structures. The ectopic pain precludes precise diagnosis and makes treatment problematic, because the underlying mechanism is not well understood.
Masaaki Kiyomoto, Masamichi Shinoda, Kuniya Honda, Yuka Nakaya, Ko Dezawa, Ayano Katagiri, Satoshi Kamakura, Tomio Inoue, Koichi Iwata   +8 more
doaj   +1 more source

Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: The streptomycete derived farnesyltransferase inhibitor Manumycin A triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy.
Jasmin Egler, Jens Zierle, Florian Lang
doaj   +1 more source

Targeting the CTBP1–CETP axis overcomes ferroptosis resistance in non‐small cell lung cancer by altering lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CTBP1‐driven CETP activation orchestrates lipid accumulation to suppress MAPK‐dependent ferroptosis in non‐small cell lung cancer. Repurposing the clinical‐stage CETP inhibitor obicetrapib successfully overcomes this resistance in NSCLC patient‐derived organoids, highlighting a promising translational therapeutic strategy. Abstract Background Non‐small
Yanjie Chen, Heng Wang, Ximin Tan, Chenxi Yan, Fangfang Liu, Shuxuan Deng, Chengyan Wang, Yangchen Xia, Zhaolin Xu, Kongming Wu, Shanshan Huang, Qian Chu   +11 more
wiley   +1 more source