Results 71 to 80 of about 15,652 (174)

Role of Autophagy on Cobrotoxin Induced Cell Death of A549

Chinese Journal of Lung Cancer, 2013
Background and objective It has been proven that cobrotoxin has anti-tumor effect while its role in lung cancer is rarely studied. The aim of this study is to assay the anti-tumor effect of cobrotoxin in cell line A549, and also to explore its possible ...
Jian SHEN, Jingkang HE, Xing TANG, Rong HAN, Rui LI, Chengcheng XU, Yajuan WU   +6 more
doaj   +1 more source

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source

SB203580, a P38 MAPK Inhibitor, Blocks in vitro Invasion by Human Gastric SNU-638 Cells

Cancer Research and Treatment, 2002
The role of P38 mitogen-activated protein kinase (MAPK) in gastric cancer invasion has not yet been determined. In this study, we examined the effects of SB203580, a specific P38 MAPK inhibitor, on the in vitro invasion of gastric cancer and upon the molecules involved in this process.Human gastric cancer SNU-638 cells were maintained in RPMI 1640 ...
Ju Chae, Park, Hyeon Gyeung, Yoo, Hong Su, Kim, Min A, Jung, Mi Ha, Kim, Sang Won, Han, Kee Oh, Chay, Boo Ahn, Shin, Bong Whan, Ahn, Young Do, Jung   +9 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase Regulates Vasoconstriction in Spontaneously Hypertensive Rats

Journal of Pharmacological Sciences, 2004
We investigated whether p42/p44 mitogen-activated protein kinase (MAPK) and/or p38 MAPK participates in the regulation of vascular smooth muscle contraction by endothelin-1 (ET-1) in Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR).
Seongchun Kwon, Lian Hua Fang, Bokyung Kim, Tae-Seon Ha, Sang Jin Lee, Hee Yul Ahn   +5 more
doaj   +1 more source

The efficacy and potential mechanism of cnidium lactone to inhibit osteoclast differentiation

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Cnidium lactone is effective in the maintenance of bone mass in various osteoporosis models; however, the precise molecular mechanisms are not understood.
Jun-Yang Liang, Wen-Liang Wu, Yun-Xia Chen, Haichun Liu   +3 more
doaj   +1 more source

In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580

International Journal of Chronic Obstructive Pulmonary Disease, 2016
Aihong Meng,1 Xiaopeng Zhang,2 Siyu Wu,1 Mingxia Wu,1 Jing Li,1 Xixin Yan,1 Kamilla Kopec-Harding,3 Jiakai Wu41Respiratory Division, The Second Hospital of Hebei Medical University, 2Department of Thoracic Surgery, Hebei Province General Hospital, Shijiazhuang, Hebei, Peoples’ Republic of China; 3Centre for Musculoskeletal Research, 4Centre ...
Meng,Aihong, Zhang,Xiaopeng, Wu,Siyu, Wu,Mingxia, Li,Jing, Yan,Xixin, Kopec-Harding,Kamilla, Wu,Jiakai   +7 more
openaire   +3 more sources

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Cell Death and Disease
p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including SB203580 and SB202190, induce cell death in some cancer cell-types through ...
Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton   +8 more
doaj   +1 more source

Role of SB203580 in the regulation of human esophageal cancer cells under the effection of Diosgenin.

International journal of clinical and experimental medicine, 2015
In order to investigate the mechanism of human esophageal Eca109 cells induced by Diosgenin (Dio), the p38 specific inhibitor SB203580 was used to inhibit the expression of p38 and Western blot was employed to detect the effect of SB203580 in Eca109 cells. MTT experiments were executed to detect the proliferation of the cells.
Weiliang, Ding, Yancai, Jiang, Yaping, Jiang, Taofeng, Zhu, Ying, Xu, Wenjie, Jiang, Wenjiao, Zhu, Zhian, Tang, Zhijun, Ge, Tieliang, Ma, Yongfei, Tan   +10 more
openaire   +1 more source

Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathway in vivo and in vitro

Journal of Ginseng Research
Background: Ginsenosides have been used in traditional Chinese medicine to treat fractures. Ginsenoside Re, a key component of P. ginseng, however, the molecular mechanisms underlying these effects remain inadequately understood.
Yunjia Wang, Gengming Zhang, Linhua Deng, Hongqi Zhang, Emmanuel Alonge, Zhongjing Jiang   +5 more
doaj   +1 more source

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

Frontiers in Pharmacology, 2018
Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive.
Ya-wei Zhao, Ya-wei Zhao, Yu-qin Pan, Yu-qin Pan, Ming-ming Tang, Wen-juan Lin, Wen-juan Lin   +6 more
doaj   +1 more source