Results 71 to 80 of about 18,824 (215)
Effects of mechanical stress and the p38 inhibitor SB203580 on aggrecan and type II collagen mRNA expression during mechanical loading. [PDF]
, 2014 (A) Effect of MS combined with the p38 inhibitor SB203580 on AGC gene expression at different concentrations (10, 20 µM). (B) Effect of the p38 inhibitor SB203580 on Col2 gene expression.
Suguru Shioji (670607) +4 more
core +1 more source
Drug Design, Development and Therapy, 2019 Jian-Wei Lin,1 Le-He Yang,2 Zhuo-Chao Ren,3 De-Guang Mu,3 Ya-Qing Li,3 Jian-Ping Yan,3 Liang-Xing Wang,4 Chun Chen31Department of Cardiology, Xiasha Campus, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310018, Zhejiang ...
Lin JW +7 more
doaj
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin +12 more
wiley +1 more source
Rosiglitazone and SB203580 attenuated activation of fibroblast motility induced by TGF-β1. [PDF]
, 2014 Stimulation with TGF-β1 significantly improved the fibroblast motility compared with control group (p0.05). Cells were seeded in six-well plates, and scratch wounds were performed.
Xiao-Jian Guo (619451) +4 more
core +1 more source
Journal of Pharmacological Sciences, 2007 In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee +11 more
doaj +1 more source
ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice
Obesity, Volume 34, Issue 8, Page 1635-1646, August 2026.ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen +8 more
wiley +1 more source
Effect of SB203580 on apoptosis related gene expression pattern of SEB in human PBMCs
The FASEB Journal, 2009 Here we attempt to utilize a well characterized set of apoptotic related genes that are key to the pathogenesis of Staphylococcal Enterotoxin B (SEB) induced lethal shock in human peripheral blood mononuclear cells (PBMC) to evaluate the effectiveness of a potential inhibitor of apoptosis related events.
Tricia Nicole Mason +2 more
openaire +1 more source
Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580 [PDF]
Journal of Biological Chemistry, 2003 The proximal promoter sequence of the interleukin-2 (IL-2) gene contains a series of composite sites or modules that controls much of its responsiveness to environmental stimuli. The integrated targeting of these modules is therefore a major mode of regulation.
James L, Smith +8 more
openaire +2 more sources
SB203580 Enhances LPS-Induced G-CSF Production in Macrophages by Increasing G-CSF mRNA Stability [PDF]
, 2013 顆粒性白血球群落刺激性因子 (Granulocyte colony-stimulating factor, G-CSF)是造血醣蛋白生長因子的成員之一，具有調控嗜中性白血球分化增生的能力。G-CSF可以經過LPS、IL-1β及TNF-α的刺激透過轉錄及後轉錄調控機制由內皮細胞、巨噬細胞及其他許多免疫細胞分泌。G-CSF mRNA三端未轉譯區 (3’ untranslated region, 3’UTR) 含有數個AUUUA序列 (adenosine uridine-rich elements, ARE)
Tsai, Wen-Ju, 蔡雯茹
core
Materials Today BioPhotodynamic therapy (PDT) has emerged as an ideal candidate among reactive oxygen species (ROS)-mediated tumor therapies. However, the self-repair of DNA, a hallmark of mechanism induced by excessive intracellular ROS is one of the leading causes of PDT
Yanting Sun +9 more
doaj +1 more source