Results 71 to 80 of about 19,858 (214)
Journal of Pharmacological Sciences, 2007 In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee +11 more
doaj +1 more source
LMTK2 Inhibits Metastasis of Colon Cancer Cells Through p38 MAPK
Cancer Science, Volume 117, Issue 11, Page 3039-3051, November 2026.LMTK2 suppresses colon cancer metastasis by acting as a kinase‐independent scaffold that directly binds p38, blocking its interaction with MKK3/6 and subsequent phosphorylation, thereby inhibiting the downstream pro‐metastatic gene program. ABSTRACT Metastasis is the leading cause of death in patients with colon cancer. Although Lemur tyrosine kinase 2
Jie Lun +6 more
wiley +1 more source
The FASEB Journal, 2008 We previously reported a defect in beta adrenergic responsiveness in cardiac myoctes isolated from pre‐natally stressed rats (PS) following restraint stress (R) (PS+R). We now report a reversal of the blunted beta adrenergic responsiveness in PS + R with the P38 MAP kinase inhibitor, SB203580, in vivo.
Fangping Chen +6 more
openaire +1 more source
Effect SB203580 of on Ox-LDL-induced mineralization in cultured VSMCs (n = 3).
, 2013 Cells were grown in control medium (in DMSO), 50 µg/ml Ox-LDL alone (in DMSO), 50 µg/ml Ox-LDL supplemented with 5 µM SB203580 (in DMSO), 5 µM C2-ceramide alone (in DMSO) or 5 µM C2-ceramide supplemented with 5 µM SB203580 (in DMSO) for 24 hours.
Meihong Ye (498236) +8 more
core +1 more source
Materials Today BioPhotodynamic therapy (PDT) has emerged as an ideal candidate among reactive oxygen species (ROS)-mediated tumor therapies. However, the self-repair of DNA, a hallmark of mechanism induced by excessive intracellular ROS is one of the leading causes of PDT
Yanting Sun +9 more
doaj +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
The mechanism of Qijing Mingmu decoction on cellular senescence of conjunctivochalasis
BMC Complementary Medicine and Therapies, 2023 Background Qijing Mingmu decoction (QJMM), a compound Chinese medicine preparation, which consists of Lycium barbarum, Polygonatum, Ophiopogon japonicus, Poria cocos, Glycyrrhiza, Eclipta prostrata and Ligusticum striatum, has been confirmed to be ...
Minhong Xiang +6 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Pharmacological inhibition of glutaminase with drug CB‐839 restores mitochondrial function in senescent myoblasts and enhances muscle strength and endurance in progeria mice. ABSTRACT Age‐associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction.
Hamsa Vardini Senthil Kumar +7 more
wiley +1 more source
p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis
Oncology Reports, 2006 Sulindac sulfone (exisulind), is a promising anticancer agent because of its ability to induce apoptosis in a variety of malignant cell types and its minimal toxicity to normal cells. The induction of apoptosis is thought to account for the growth inhibitory effect of exisulind. The mitogen-activated protein kinase (MAPK) cascade has been implicated in
Soo-Jeong, Lim +2 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2018 Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear.
Yui Yamazaki +3 more
doaj +1 more source