Results 91 to 100 of about 18,824 (215)
Programmed Cell Death in Chronic Rhinosinusitis
Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu +5 more
wiley +1 more source
SB203580 treatment reduces TNF-α in DENV-infected mice. [PDF]
, 2016 Mice were infected with 4 × 105 FFU/ml of DENV and treated with 2%DMSO (v/v) or SB203580 dissolved in 2%DMSO. The control (uninfected) group was treated with 2%DMSO (v/v) alone.
Sansanee Noisakran (109150) +6 more
core +1 more source
Frontiers in Immunology, 2018 There is now compelling evidence that tumor necrosis factor (TNF) preferentially activates and expands CD4+Foxp3+ regulatory T cells (Tregs) through TNF receptor type II (TNFR2).
Tianzhen He +6 more
doaj +1 more source
Drug Development Research, Volume 87, Issue 4, June 2026.ABSTRACT Santamarine (SAMA), a Michelia compressa‐derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated SAMA and cisplatin's combined effects and underlying ROS/MAPK mechanisms of action on oral cancer cells ...
Hsin‐I. Lu +8 more
wiley +1 more source
Role of SLDE in G-CSF 3'UTR mediates increase of mRNA stability induced by SB203580 [PDF]
, 2013 顆粒性白血球群落刺激因子(G-CSF)為造血性醣蛋白家族中的一員，也是一種細胞激素，主要由巨噬細胞及單核球細胞所分泌，具有促進噬中性白血球分化、增生及移動的功能。細胞受到LPS刺激活化p38 MAPK會使G-CSF mRNA穩定度增加，增加G-CSF表現。G-CSF mRNA的穩定度主要由 3''UTR的ARE及SLDE所調控。許多研究顯示給予SB203580抑制p38 MAPK活性後，會使在3’UTR帶有ARE的mRNA半衰期變短，進而降低其表現量。但是本實驗室先前的研究結果發現 ...
Li, Huai-Tzu, 黎懷慈
core
Aquaculture ReportsThe SB203580 inhibitor, a blocker of the p38MAPK pathway, has been widely studied for bioimmune applications. To investigate its immune effect of Vibrio parahaemolyticus on Pinctada fucata martensii, the key genes, PmMKK6 and PmCREB, downstream of the ...
Jie Chen +4 more
doaj +1 more source
Cell Proliferation, Volume 59, Issue 6, June 2026.Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie +6 more
wiley +1 more source
Role of Autophagy on Cobrotoxin Induced Cell Death of A549
Chinese Journal of Lung Cancer, 2013 Background and objective It has been proven that cobrotoxin has anti-tumor effect while its role in lung cancer is rarely studied. The aim of this study is to assay the anti-tumor effect of cobrotoxin in cell line A549, and also to explore its possible ...
Jian SHEN +6 more
doaj +1 more source
SB203580 treatment reduces the phosphorylation of ATF-2. [PDF]
, 2016 Proteins were extracted from the liver tissue samples of 2%DMSO-treated (uninfected), 2%DMSO-treated DENV-infected, and SB203580-treated DENV-infected groups of mice.
Sansanee Noisakran (109150) +6 more
core +1 more source
SB203580, a P38 MAPK Inhibitor, Blocks in vitro Invasion by Human Gastric SNU-638 Cells
Cancer Research and Treatment, 2002 The role of P38 mitogen-activated protein kinase (MAPK) in gastric cancer invasion has not yet been determined. In this study, we examined the effects of SB203580, a specific P38 MAPK inhibitor, on the in vitro invasion of gastric cancer and upon the molecules involved in this process.Human gastric cancer SNU-638 cells were maintained in RPMI 1640 ...
Ju Chae, Park +9 more
openaire +2 more sources