Results 111 to 120 of about 19,858 (214)

Apoptotic gene expression profiles of DMSO-treated DENV-infected mice and SB203580 treated DENV-infected mice (both are normalized with those of DMSO-treated uninfected mice).

, 2016
Apoptotic gene expression profiles of DMSO-treated DENV-infected mice and SB203580 treated DENV-infected mice (both are normalized with those of DMSO-treated uninfected mice).
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

P38 mitogen-activated protein kinase inhibition attenuates mechanical stress induced lung injury via up-regulating AQP5 expression in rats

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to detect aquaporin-5 (AQP5) expression and evaluate the role of the p38-MAPK signalling pathway in mechanical ventilation-associated lung injury. Rats were randomly divided into 5 groups.
Yang Liu, Yuelan Wang, Xiumei Song, Ling Dong, Wei Wang, Hongchao Wu   +5 more
doaj   +1 more source

Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in endoplasmic reticulum stress (ERS) and inflammation, which may play an important role in the pathogenesis of type 2 diabetes (T2DM).
Xiaowei Wei, Nan Gu, Nan Feng, Xiaohui Guo, Xiaowei Ma   +4 more
doaj   +1 more source

SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3 ' untranslated region in macrophages independently of its effect on p38 MAPK activity

, 2017
Background: Granulocyte-colony stimulating factor (G-CSF) is a major regulator of the production and survival of neutrophils. Regulation of G-CSF expression is complex and occurs at both transcription and post-transcription levels.
Chang, Shwu-Fen;Li, Huai-Ci;Huang, Yu-Pei;Tasi, Wen-Ju;Chou, Yuan-Yi;Lu, Shao-Chun, 呂紹俊   +1 more
core   +1 more source

SB203580 treatment reduces liver enzymes in DENV-infected mice.

, 2016
Mice were infected with DENV and treated with 2%DMSO or SB203580. The uninfected control group was also treated with 2%DMSO. Seven days after infection, blood was collected and sera prepared to estimate liver transaminases. (A) ALT, and (B) AST.
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

Rosiglitazone and SB203580 attenuated fibroblast proliferation induced by TGF-β1.

, 2014
(A) Cell Counting Kit-8 assays showed that treatment with TGF-β1 significantly increased the proliferation of fibroblasts after 24 h (p0.05). The inhibitory effect of SB203580 on TGF-β1 stimulated cell proliferation was weaker than the effect of ...
Xiao-Jian Guo (619451), Jiao Tian (583054), Yong-Heng Luo (619449), Ping-Bo Ouyang (619450), Xuan-Chu Duan (619452)   +4 more
core   +1 more source

The effect of MAPKs inhibitor on platelet aggregation mediated by IL-17A combined with ADP.

, 2013
(A) Representative pictures for platelet aggregation response to U0126, SB203580, SP600125 and CTRL (without any intervention). (B) The results of statistical analysis for ratio of platelet aggregation response to U0126, SB203580, SP600125 and CTRL ...
He-Ping Guo (316308), Jing Yuan (217967), Hong Fan (146238), Rui Yang (293531), Yu-Hua Liao (168020), Min Wang (21070), Shuang Zhang (117657), Miao Yu (199182), Zhang-Qiang Guo (316307)   +8 more
core   +1 more source

SB203580 enhances interleukin-1 receptor antagonist gene expression in IFN-γ-stimulated BV2 microglial cells through a composite nuclear factor-κB/PU.1 binding site

, 2019
Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring antagonist of IL-1α and IL-1β binding to the IL-1 receptors and alleviates various inflammatory reactions.
박진선, 김희선
core   +1 more source

The Effect of SB203580, an Inhibitor of P38MAPK, on HK-2 Cells TEMT

Hong Kong Journal of Nephrology, 2015
Jia, L., Yang, X.P., Lin, Z.F., Tang, Y.L., Yang, R., Ma, L.   +5 more
openaire   +1 more source

p38 MAPK 抑制剂通过抑制JNK 活性抑制培养的小脑颗粒神经元凋亡

Zhongshan Daxue xuebao. Yixue kexue ban, 2001
【目的】研究特异性p38 分裂原激活的蛋白激酶(MAPK)抑制剂SB203580 对低钾诱导的小脑颗粒神经元凋亡的 作用。【方法】把体外培养的小脑颗粒神经元从含去极化浓度钾离子(KCl 25 mmo l·L-1)的培养基中转移至低钾培养基(KCl 5 mmol·L-1)中诱导神经元凋亡。凝胶电泳分析DNA 片段, SAPK/ JNK 分析盒测定c-Jun N-末端蛋白激酶(JNK)活性。【结 果】低钾诱导小脑颗粒神经元的具有典型形态学和生化特征的凋亡。特异性的p38 MAPK ...
黎明涛, 王文雅, 孙　娟, 唐孝礼, 苏兴文, 邱鹏新, 颜光美   +6 more
doaj