Results 111 to 120 of about 18,824 (215)

Rescue of TGF-beta-downregulated TMEM16A expression by a Smad3 inhibitor (SIS3) and CFTR expression by a p38 MAPK inhibitor (SB203580). [PDF]

, 2014
T84 cells and HAECs were treated with either TGF-beta and SIS3 (5 µM, A and C) or TGF-beta and SB203580 (10 µM, B and D) for 48 h prior to lysis and immunoblot for TMEM16A (A and C) or CFTR (B and D). For each cell type, the upper gel panels show TMEM16A
Yan Sanders (636855), Anusha Sridharan (634793), Alicia J. Ostmann (456924), Amir Rezayat (456925), Stephanie Kortyka (636853), William T. Harris (444214), Hongtao Sun (456928), Anjaparavanda P. Naren (583409), John P. Clancy (438294), Kavitha Kotha (636854)   +9 more
core   +1 more source

Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathway in vivo and in vitro

Journal of Ginseng Research
Background: Ginsenosides have been used in traditional Chinese medicine to treat fractures. Ginsenoside Re, a key component of P. ginseng, however, the molecular mechanisms underlying these effects remain inadequately understood.
Yunjia Wang, Gengming Zhang, Linhua Deng, Hongqi Zhang, Emmanuel Alonge, Zhongjing Jiang   +5 more
doaj   +1 more source

Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 [PDF]

, 2004
Activated mast cells generate multiple cytokines but it is not known if these can be differentially regulated by pharmacological agents. We report here that the glucocorticoid dexamethasone (DEX) preferentially inhibited Ag-induced expression of IL-4 and
Flanagan, B. F., Dearman, R. J., Swindle, E. J., Kimber, I., Koranteng, R. D., Coleman, J. W., Davis, B. J.   +6 more
core   +1 more source

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

Frontiers in Pharmacology, 2018
Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive.
Ya-wei Zhao, Ya-wei Zhao, Yu-qin Pan, Yu-qin Pan, Ming-ming Tang, Wen-juan Lin, Wen-juan Lin   +6 more
doaj   +1 more source

The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway

Frontiers in Pharmacology
BackgroundAcorus tatarinowii Schott holds a prominent position in Traditional Chinese Medicine, with its earliest record found in the ancient Chinese pharmacopeia, the Shennong’s Classic of Materia Medica.
Xing Wei, Xing Wei, Kexin Sun, Peng Feng, Shuang Huang, Bing Jiang, Min Cui, Yuanhuan Chen, Fuchun Xue, Yuezhen He, Jingxi Yao, Jing Shang, Hao Mei, Yanqing Ding, Yongyan Tian, Guangyu Guo, Nan Yang, Zhenggang Shi   +17 more
doaj   +1 more source

Protective effects of the p38 MAPK inhibitor SB203580 on NMDA-induced injury in primary cerebral cortical neurons

Molecular Medicine Reports, 2014
The p38 pathway, which is important in mitogen-activated protein kinase (MAPK) family protein signaling, leads to mitochondrial dysfunction and activation of caspase-3. B-cell lymphoma 2 (Bcl‑2) family members are involved in the regulation of activities associated with the survival and death of neurons through apoptosis and have important functions in
Xue-Wen, Liu, En-Fei, Ji, Peng, He, Rui-Xian, Xing, Bu-Xian, Tian, Xi-Dong, Li   +5 more
openaire   +3 more sources

Neuroprotective effects of SB203580 (p38 MAP kinase inhibitor) against Endothelin-1-induced retinal ganglion cell death [PDF]

, 2020
Purpose: Endothelin-1 (ET-1) is a vasoactive peptide contributing to neurodegeneration in glaucoma, however, the underlying mechanisms are not completely understood.
Krishnamoorthy, Vignesh, Chaphalkar, Renuka, Krishnamoorthy, Raghu, He, Shaoqing, Kodati, Bindu   +4 more
core  

SB203580 does not reduce the phosphorylation of p38 MAPK. [PDF]

, 2016
Proteins were extracted from the liver tissue samples of 2%DMSO-treated (uninfected), 2%DMSO-treated DENV-infected, and SB203580-treated DENV-infected groups of mice.
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

P38 mitogen-activated protein kinase inhibition attenuates mechanical stress induced lung injury via up-regulating AQP5 expression in rats

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to detect aquaporin-5 (AQP5) expression and evaluate the role of the p38-MAPK signalling pathway in mechanical ventilation-associated lung injury. Rats were randomly divided into 5 groups.
Yang Liu, Yuelan Wang, Xiumei Song, Ling Dong, Wei Wang, Hongchao Wu   +5 more
doaj   +1 more source

β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells

Journal of the Formosan Medical Association, 2012
Nuclear localization of β-catenin is known to associate with malignant transformation of many squamous cell carcinomas. The aim of this study was to compare β-catenin expression in normal human oral epithelium and areca quid chewing associated oral ...
Shiuan-Shinn Lee, Chung-Hung Tsai, Lo-Lin Tsai, Ming-Chih Chou, Ming-Yung Chou, Yu-Chao Chang   +5 more
doaj   +1 more source