Results 131 to 140 of about 15,652 (174)

The p38 MAPK inhibitor, SB203580, inhibits cell invasion by Neospora caninum

Parasitology Research, 2016
The Apicomplexan parasite Neospora caninum is an obligate intracellular parasitic protozoan. It can cause severe diseases in a number of animals throughout the world. Infection with N. caninum leads to abortions in pregnant animals and neuromuscular disorders of newborns which cause great economic losses to animal husbandry.
Pengtao Gong   +2 more
exaly   +3 more sources

p38 Inhibitor SB203580 sensitizes the resveratrol‐induced apoptosis in human lung adenocarcinoma (A549) cells

Journal of Biochemical and Molecular Toxicology, 2012
AbstractBased on our recent findings that resveratrol, a natural plant polyphenol found in red grape skins as well as other food products, induces apoptosis via a caspase‐independent intrinsic pathway in human lung adenocarcinoma cells, this study is designed to explore whether SB203580, a p38 inhibitor, potentiates the resveratrol‐induced apoptosis of
Haiyang Li, Junle Qu
exaly   +4 more sources

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK

Apoptosis: an International Journal on Programmed Cell Death, 2011
SB203580 is a well-known inhibitor of p38 mitogen-activated protein kinase (MAPK). However, it can suppress cell proliferation in a p38 MAPK independent manner. The inhibitory mechanism remains unknown. Here, we showed that SB203580 induced autophagy in human hepatocellular carcinoma (HCC) cells.
George G Chen   +2 more
exaly   +3 more sources

The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical

Basic Research in Cardiology, 2000
There is debate concerning the involvement of p38 mitogen activated protein kinase (MAPK) in the mediation of ischaemic preconditioning. Pharmacological inhibition of p38 MAPK with SB203580 has been reported to block preconditioning in some studies but not in others.
Mihaela M Mocanu   +2 more
exaly   +3 more sources

SB203580 promote EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway

Journal of Cellular Biochemistry, 2001
AbstractMAP kinases have important role in PC12 cell differentiation, since the activities of both extracellular regulated protein kinase (ERK) and p38 have been indicated as necessary signal for PC12 cell differentiation. Epidermal growth factor (EGF) and NGF both activate ERK and p38 in PC12 cells, but only NGF trigger differentiation.
Liguo New, Yingqiu Li, Baoxue Ge
exaly   +3 more sources

SB203580 reverses adrenomedullin's effect on proliferation and apoptosis in cultured mesangial cells

European Journal of Pharmacology, 1999
Adrenomedullin is a potent vasodilatory peptide that has a variety of effects in a number of different systems including kidney. In cultured rat glomerular mesangial cells adrenomedullin increases cAMP, decreases proliferation and increases apoptosis. Associated with the anti-proliferative and apoptotic effects, adrenomedullin also causes a decrease in
N, Parameswaran   +3 more
openaire   +2 more sources

Influence of SB203580 on cell apoptosis and P38MAPK in renal ischemia/reperfusion injury

Journal of Huazhong University of Science and Technology [Medical Sciences], 2006
The effects of SB203580 (SB) with different concentrations at different time points on renal function, apoptosis, P38MAPK activity and the expression, as well as the P38MAPK substrates in renal ischemia/reperfusion injury were investigated. Forty-nine rats were divided into 7 groups at random (n = 7 in each group) according to the durations of ischemia/
Rongshan, Li   +3 more
openaire   +2 more sources

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