Results 151 to 160 of about 15,652 (174)

Cilostazol and SB203580 combination: Targeting ER stress and p38MAPK signaling in Alzheimer's disease mouse model

European Journal of Pharmacology
Endoplasmic reticulum (ER) stress and mitogen-activated protein kinase (p38MAPK) signaling contribute to neuronal inflammation, oxidative stress, and apoptosis, driving neurodegeneration in Alzheimer's disease (AD). These pathways present potential therapeutic targets.
May Magdy Ali, Rabab Hamed Sayed, Walaa Wadie, Reham Atef Mohammed   +3 more
openaire   +2 more sources

[P38 MAPK inhibitor SB203580 attenuates the toxicity of ropivacaine on PC12 cells].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2019
To investigate the effect of SB203580, a p38MAPK specific inhibitor, on ropivacaine-induced cytotoxicity in PC12 cells.
 Methods: PC12 cells were divided into three groups: the normal group (Group N), cells were cultured for 48 h; the ropivacaine group (Group R), cells were cultured with 15 mmol/L ropivacaine hydrochloride for 48 h; the ropivacaine ...
Yuan, Chen, E, Wang, Zhihua, Sun, Zongbin, Song, Zhi, Ye, Zhong, Zhang   +5 more
openaire   +1 more source

Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia.

Acta neurologica Scandinavica, 2004
Focal cerebral ischemia activates intracellular signaling pathways including the mitogen-activated protein kinase p38, which may be involved in the process of ischemic brain injury. In this study, the effect of pretreatment with the p38-inhibitor SB203580 on infarct size and blood-brain barrier (BBB) breakdown was investigated with magnetic resonance ...
F, Lennmyr, A, Ericsson, P, Gerwins, H, Ahlström, A, Terént   +4 more
openaire   +2 more sources

SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1–42 into hippocampus of mice

Metabolic Brain Disease, 2016
A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selective inhibitor of p38MAPK, may protect
Jiejie, Guo, Lan, Chang, Chenli, Li, Mengmeng, Li, Peiyun, Yan, Zhiping, Guo, Chuang, Wang, Qin, Zha, Qinwen, Wang   +8 more
openaire   +2 more sources

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

Biochemical and Biophysical Research Communications, 1999
Phosphorylation of p53 at serine 389 has been shown to be responsive uniquely to UV but not gamma irradiation. This report describes identification of the UV-responsive p38MAPK protein as a serine 389 kinase. The immunoprecipitated p38MAPK from UV-irradiated murine embryonic testicular carcinoma F9 cells phosphorylated the serine 392 residue but not ...
D, Keller, X, Zeng, X, Li, M, Kapoor, M S, Iordanov, Y, Taya, G, Lozano, B, Magun, H, Lu   +8 more
openaire   +2 more sources

[Mechanism of p38 mitogen-activated protein kinase inhibitor SB203580 to glucocorticoid sensitivity].

Zhonghua yi xue za zhi, 2013
To establish a model of cigarette smoke exposure to asthmatic rats and glucocorticoid resistance induced by nicotine in alveolar epithelioid cells A549 and study the mechanism for the change of glucocorticoid sensitivity induced by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580.Sixty Wistar rats were randomly divided into 4 groups ...
Wen, Li, Jiang-tao, Lin, Li-chao, Sun, Tong-liang, Zhou, Lan, Zhang, Jun, Shu   +5 more
openaire   +1 more source

Cytosolic Phospholipase A2 Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells

The Journal of Pharmacology and Experimental Therapeutics, 2001
SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole] is widely used as a specific inhibitor of p38 mitogen-activated protein kinase (MAPK). Here we report that SB203580, which blocked p38 kinase activation elicited by anisomycin, increased the phosphorylation and activity of cytosolic phospholipase A2 (cPLA2) and ...
S, Fatima, Z, Khandekar, J H, Parmentier, K U, Malik   +3 more
openaire   +2 more sources

[Effects of SB203580 and WP631 on Smad signal transduction pathway in lung fibroblasts after irradiation].

Ai zheng = Aizheng = Chinese journal of cancer, 2009
Radiation pulmonary fibrosis (RPF) is characterized by fibroblast proliferation and excessive accumulation of extracellular matrix (ECM). Transforming growth factor beta (TGFbeta) is a switch factor in the initiation and development of RPF and serves as a therapeutic target. Blocking TGFbeta1 signal transduction pathway might alleviate RPF.
Yang, Li, Liang-Wen, Song, Rui-Yun, Peng, De-Wen, Wang, Mei-Hong, Jin, Ya-Bing, Gao, Jun-Jie, Ma   +6 more
openaire   +1 more source

p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells

Biochemical and Biophysical Research Communications, 2023
Utpal Ghosh
exaly  

Effects of the p38 MAP kinase inhibitor SB203580 on the immune system of rats

Annual Meeting of the Japanese Society of Toxicology, 2005
Shibata, Seiji, Katsuta, Motoko, Isobe, Mitsui, Ikeda, Takashi, Araki, Sei-ichi, Ootake, Sachiyo, Hisada, Shigeru   +6 more
openaire   +1 more source